Weinstein E S, Hampton W W, Yokum M D, Fry D E
J Trauma. 1986 Jul;26(7):620-4.
Subsarcolemmal (SS) and interfibrillar (IF) cardiac mitochondrial respiratory activities were examined under conditions of isovolemic hemodilution in rats. Experimental animals (mean Hct, 21%) had significantly higher cardiac indices than controls (mean Hct, 41.5%) 18 hours following isovolemic hemodilution with 0.9% NaCl. A 40% increase in cardiac output was associated with a significant increase in the respiratory control index (RCI) of the IF mitochondria. This increase in IF RCI occurred as a result of a significant decline in the ADP-independent (State 4) respiratory rate. These data demonstrate the ability of cardiac mitochondria to respond to increased myocardial demand by increasing mitochondrial efficiency and support the concept of subspecialized populations of mitochondria within the myocardial cell.
在大鼠等容血液稀释条件下，检测了肌膜下（SS）和肌原纤维间（IF）心脏线粒体的呼吸活性。用0.9%氯化钠进行等容血液稀释18小时后，实验动物（平均血细胞比容，21%）的心脏指数显著高于对照组（平均血细胞比容，41.5%）。心输出量增加40%与IF线粒体的呼吸控制指数（RCI）显著增加相关。IF RCI的这种增加是由于不依赖ADP的（状态4）呼吸速率显著下降所致。这些数据证明了心脏线粒体通过提高线粒体效率来应对增加的心肌需求的能力，并支持心肌细胞内存在亚专业化线粒体群体的概念。
