Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh 517502, India.
Environ Toxicol Pharmacol. 2023 Jun;100:104158. doi: 10.1016/j.etap.2023.104158. Epub 2023 May 25.
Cadmium (Cd) is a heavy metal that is highly toxic to living organisms, including humans. But the dietary zinc (Zn) supplements play critical role in minimizing or preventing Cd poisoning, without any side effects. The underlying mechanisms, however, have not been thoroughly investigated. Therefore, in this study, we investigated the use of Zn as a protection against Cd toxicity in zebrafish models. The obtained results confirmed the levels of antioxidant enzymes and supported the synergistic effects of Zn in reducing Cd toxicity. The lipid, carbohydrate, and protein concentrations in the liver tissue have also been negatively impacted by Cd; however, treatment with Zn has lessened these adverse effects. Furthermore, the level of 8-hydroxy-2' -deoxyguanosine (8-OHdG), caspase-3 also confirms the protective effects of Zn in reducing DNA damage caused by Cd. The results of this study demonstrate that a Zn supplement can lessen the harmful effects of Cd in zebrafish model.
镉（Cd）是一种对包括人类在内的生物体具有高度毒性的重金属。但是，膳食锌（Zn）补充剂在最小化或预防 Cd 中毒方面起着关键作用，没有任何副作用。然而，其潜在机制尚未得到彻底研究。因此，在这项研究中，我们研究了 Zn 作为保护剂在斑马鱼模型中对抗 Cd 毒性的作用。获得的结果证实了抗氧化酶的水平，并支持了 Zn 协同作用降低 Cd 毒性的效果。肝脏组织中的脂质、碳水化合物和蛋白质浓度也受到 Cd 的负面影响；然而，Zn 的处理减轻了这些不利影响。此外，8-羟基-2'-脱氧鸟苷（8-OHdG）和 caspase-3 的水平也证实了 Zn 在减少 Cd 引起的 DNA 损伤方面的保护作用。这项研究的结果表明，Zn 补充剂可以减轻 Cd 对斑马鱼模型的有害影响。
