Conte Miriam, De Feo Maria Silvia, Sidrak Marko Magdi Abdou, Corica Ferdinando, Gorica Joana, Granese Giorgia Maria, Filippi Luca, De Vincentis Giuseppe, Frantellizzi Viviana
Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00161 Rome, Italy.
Department of Nuclear Medicine, Santa Maria Goretti Hospital, 00410 Latina, Italy.
Diagnostics (Basel). 2023 May 9;13(10):1682. doi: 10.3390/diagnostics13101682.
(1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging represents a pivotal instrument to guide clinicians. This systematic review aims to summarize the current and novel PET tracers. (2) Methods: Literature research was conducted on Pubmed, Scopus, Medline, Central, and the Web of Science using the query "pet ligands" and "tauopathies". Articles published from January 2018 to 9 February, 2023, were searched. Only studies on the development of novel PET radiotracers for imaging in tauopathies or comparative studies between existing PET tracers were included. (3) Results: A total of 126 articles were found, as follows: 96 were identified from PubMed, 27 from Scopus, one on Central, two on Medline, and zero on the Web of Science. Twenty-four duplicated works were excluded, and 63 articles did not satisfy the inclusion criteria. The remaining 40 articles were included for quality assessment. (4) Conclusions: PET imaging represents a valid instrument capable of helping clinicians in diagnosis, but it is not always perfect in differential diagnosis, even if further investigations on humans for novel promising ligands are needed.
(1) 背景：tau蛋白病是一组以异常tau蛋白沉积为特征的疾病。它们可分为3R、4R和3R/4R tau蛋白病，还包括阿尔茨海默病（AD）和慢性创伤性脑病（CTE）。正电子发射断层扫描（PET）成像为临床医生提供了关键指导。本系统评价旨在总结当前和新型PET示踪剂。(2) 方法：在Pubmed、Scopus、Medline、Central和Web of Science上进行文献研究，检索词为“pet配体”和“tau蛋白病”。检索2018年1月至2023年2月9日发表的文章。仅纳入关于新型PET放射性示踪剂用于tau蛋白病成像的研究或现有PET示踪剂之间的比较研究。(3) 结果：共检索到126篇文章，具体如下：96篇来自PubMed，27篇来自Scopus，1篇来自Central，2篇来自Medline，Web of Science上为0篇。排除24篇重复文章，63篇文章不符合纳入标准。其余40篇文章纳入质量评估。(4) 结论：PET成像有助于临床医生进行诊断，是一种有效的手段，但在鉴别诊断方面并不总是完美的，尽管还需要对新型有前景的配体进行更多人体研究。
