关于量化掌指关节软骨健康状况的成分性磁共振生物标志物年龄依赖性的见解。
Insights into the Age Dependency of Compositional MR Biomarkers Quantifying the Health Status of Cartilage in Metacarpophalangeal Joints.
作者信息
Frenken Miriam, Radke Karl Ludger, Schäfer Emilia Louisa Ernestine, Valentin Birte, Wilms Lena Marie, Abrar Daniel Benjamin, Nebelung Sven, Martirosian Petros, Wittsack Hans-Jörg, Müller-Lutz Anja
机构信息
Department of Diagnostic and Interventional Radiology, Medical Faculty, University Hospital of Dusseldorf, D-40225 Dusseldorf, Germany.
Department of Orthopedics and Trauma Surgery, Medical Faculty, University Hospital of Dusseldorf, D-40225 Dusseldorf, Germany.
出版信息
Diagnostics (Basel). 2023 May 16;13(10):1746. doi: 10.3390/diagnostics13101746.
(1) Background: We aim to investigate age-related changes in cartilage structure and composition in the metacarpophalangeal (MCP) joints using magnetic resonance (MR) biomarkers. (2) Methods: The cartilage tissue of 90 MCP joints from 30 volunteers without any signs of destruction or inflammation was examined using T1, T2, and T1ρ compositional MR imaging techniques on a 3 Tesla clinical scanner and correlated with age. (3) Results: The T1ρ and T2 relaxation times showed a significant correlation with age (T1ρ: Kendall-τ-b = 0.3, < 0.001; T2: Kendall-τ-b = 0.2, = 0.01). No significant correlation was observed for T1 as a function of age (T1: Kendall-τ-b = 0.12, = 0.13). (4) Conclusions: Our data show an increase in T1ρ and T2 relaxation times with age. We hypothesize that this increase is due to age-related changes in cartilage structure and composition. In future examinations of cartilage using compositional MRI, especially T1ρ and T2 techniques, e.g., in patients with osteoarthritis or rheumatoid arthritis, the age of the patients should be taken into account.
(1) 背景：我们旨在使用磁共振（MR）生物标志物研究掌指（MCP）关节软骨结构和成分的年龄相关变化。(2) 方法：在一台3特斯拉临床扫描仪上，使用T1、T2和T1ρ成分磁共振成像技术，对30名无任何破坏或炎症迹象的志愿者的90个MCP关节的软骨组织进行检查，并与年龄进行关联。(3) 结果：T1ρ和T2弛豫时间与年龄呈现显著相关性（T1ρ：肯德尔τ-b = 0.3，<0.001；T2：肯德尔τ-b = 0.2，= 0.01）。未观察到T1与年龄之间存在显著相关性（T1：肯德尔τ-b = 0.12，= 0.13）。(4) 结论：我们的数据显示，T1ρ和T2弛豫时间随年龄增加。我们推测这种增加是由于软骨结构和成分的年龄相关变化所致。在未来使用成分MRI（尤其是T1ρ和T2技术）对软骨进行检查时，例如在骨关节炎或类风湿关节炎患者中，应考虑患者的年龄。
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