轻度至中度放射学髋关节骨关节炎患者的软骨 T1ρ 和 T2 弛豫时间。
Cartilage T1ρ and T2 Relaxation Times in Patients With Mild-to-Moderate Radiographic Hip Osteoarthritis.
机构信息
University of California, San Francisco.
出版信息
Arthritis Rheumatol. 2015 Jun;67(6):1548-56. doi: 10.1002/art.39074.
OBJECTIVE
To analyze region-specific T1ρ and T2 relaxation times of the hip joint cartilage in relation to presence or absence of radiographic hip osteoarthritis (OA) and presence or absence of magnetic resonance imaging (MRI)-detected cartilage defects.
METHODS
Weight-bearing radiographs and 3T MRI studies of the hip were obtained from 84 volunteers. Based on Kellgren/Lawrence (K/L) scoring of the radiographs, 54 subjects were classified as healthy controls (K/L grade ≤1) and 30 were classified as having mild or moderate radiographic hip OA (K/L grades 2 or 3, respectively). Two-dimensional fat-suppressed fast spin-echo MRI sequences were used for semiquantitative clinical scoring of cartilage defects, and a T1ρ/T2 sequence was used to quantitatively assess the cartilage matrix. The femoral and acetabular cartilage was then segmented into 8 regions and the mean T1ρ/T2 values were calculated. Differences in T1ρ and T2 relaxation times were compared between subjects with and those without radiographic hip OA, and those with and those without femoral or acetabular cartilage defects.
RESULTS
Higher T1ρ and T2 relaxation times in the anterior superior and central regions of the acetabular cartilage were seen in individuals with radiographic hip OA and those with acetabular cartilage defects compared to their respective controls (P < 0.05). In the femoral cartilage, the differences in T1ρ and T2 were not significant for any of the comparisons. Significant differences in the T1ρ and T2 values (each P < 0.05) were found in more subregions of the cartilage and across the whole cartilage when subjects were stratified based on the presence of MRI-detected cartilage defects than when they were stratified based on the presence of radiographic hip OA.
CONCLUSION
T1ρ and T2 relaxation parameters are sensitive to the presence of cartilage degeneration. Both parameters may therefore support MRI evidence of cartilage defects of the hip.
目的
分析髋关节软骨的 T1ρ 和 T2 弛豫时间在有无放射学髋关节骨关节炎（OA）和有无磁共振成像（MRI）检测到的软骨缺陷方面的区域特异性。
方法
从 84 名志愿者中获得负重 X 线片和 3T MRI 髋关节研究。根据 X 线片的 Kellgren/Lawrence（K/L）评分，54 名受试者被分为健康对照组（K/L 分级≤1），30 名被分为轻度或中度放射学髋关节 OA 组（K/L 分级 2 或 3）。二维脂肪抑制快速自旋回波 MRI 序列用于软骨缺陷的半定量临床评分，T1ρ/T2 序列用于定量评估软骨基质。然后将股骨和髋臼软骨分为 8 个区域，并计算平均 T1ρ/T2 值。比较有和无放射学髋关节 OA、有和无股骨或髋臼软骨缺陷的受试者之间 T1ρ 和 T2 弛豫时间的差异。
结果
与相应对照组相比，放射学髋关节 OA 患者和髋臼软骨缺陷患者的髋臼软骨前上和中央区域 T1ρ 和 T2 弛豫时间较高（P<0.05）。在股骨软骨中，T1ρ 和 T2 的差异在任何比较中均不显著。当根据 MRI 检测到的软骨缺陷的存在对受试者进行分层时，与根据放射学髋关节 OA 的存在对受试者进行分层相比，在软骨的更多亚区和整个软骨中发现 T1ρ 和 T2 值存在显著差异（每次 P<0.05）。
结论
T1ρ 和 T2 弛豫参数对软骨退变的存在敏感。因此，这两个参数都可能支持髋关节软骨 MRI 检测到的软骨缺陷的证据。
Zotero 插件