Abbas Banaz, Sabri Nagwa A, El-Khouly Amal A
Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 4393005, Egypt.
Biomedicines. 2023 May 22;11(5):1501. doi: 10.3390/biomedicines11051501.
Indapamide is an effective and safe antihypertensive medication showing a beneficial effect in combination with other antihypertensive agents regarding morbidity and mortality. A comparative study was performed under fasting and fed conditions to investigate the effect of food and selected single nucleotide polymorphisms in the uridine diphosphate glucuronyl transferase () gene on the pharmacokinetics and pharmacodynamics behavior of indapamide 1.5 mg sustained release. Forty-nine healthy volunteers aged 18-55 years were randomized into two groups; 25 volunteers were administered indapamide under fasting conditions and 24 under fed conditions. Genotyping of the and was done before commencing the study using predesigned TaqMan assays. Results showed that food independently decreased the value of indapamide' T by 5.5 h and increased the value of C by 8.7 ng/mL. On the other hand, all genetic variants of both SNPs had no significant impact on the values of T, C, and AUC; however, it was found that rs11740316 variant was correlated with a 2.8 h lower MRT. Finally, BMI positively correlated with longer MRT. It was concluded that none of , , or food had a significant impact on the pharmacodynamic properties. Food had a modest impact on indapamide C and T values, while there were unremarkable differences in safety and efficacy.
吲达帕胺是一种有效且安全的抗高血压药物，在与其他抗高血压药物联合使用时，对发病率和死亡率显示出有益效果。进行了一项在禁食和进食条件下的比较研究，以调查食物和尿苷二磷酸葡萄糖醛酸转移酶（）基因中选定的单核苷酸多态性对1.5毫克缓释吲达帕胺药代动力学和药效学行为的影响。49名年龄在18至55岁之间的健康志愿者被随机分为两组；25名志愿者在禁食条件下服用吲达帕胺，24名在进食条件下服用。在研究开始前，使用预先设计的TaqMan分析对和进行基因分型。结果表明，食物独立地使吲达帕胺的T值降低5.5小时，使C值升高8.7纳克/毫升。另一方面，两个SNP的所有基因变异对T、C和AUC值均无显著影响；然而，发现rs11740316变异与MRT降低2.8小时相关。最后，BMI与较长的MRT呈正相关。得出的结论是，、或食物对药效学特性均无显著影响。食物对吲达帕胺的C和T值有适度影响，而在安全性和疗效方面存在不明显差异。
