Imeshtari Valentin, Vezza Francesca, Barletta Vanessa India, Bongiovanni Andrea, Colaprico Corrado, Shaholli David, Ricci Eleonora, Carluccio Giovanna, Moretti Luca, Manai Maria Vittoria, Chiappetta Marta, Paolini Riccardo, Marte Mattia, Previte Carlo Maria, Barone Lavinia Camilla, Faticoni Augusto, Cammalleri Vittoria, Pocino Roberta Noemi, Picchioni Filippo, Kibi Shizuka, Deriu Gloria, Serruto Pasquale, Dorelli Barbara, Mazzalai Elena, Giffi Monica, Marotta Daniela, Manzi Mattia, Marasca Valentina, Cocchiara Rosario Andrea, Ciccone Federica, Pasculli Patrizia, Massetti Paola, Antonelli Guido, Mastroianni Claudio Maria, La Torre Giuseppe
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Laboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Vaccines (Basel). 2023 Apr 22;11(5):882. doi: 10.3390/vaccines11050882.
Since the beginning of the pandemic, five variants of epidemiological interest have been identified, each of them with its pattern of symptomology and disease severity. The aim of this study is to analyze the role of vaccination status in modulating the pattern of symptomatology associated with COVID-19 infection during four waves.
Data from the surveillance activity of healthcare workers were used to carry out descriptive analysis, association analyses and multivariable analysis. A synergism analysis between vaccination status and symptomatology during the waves was performed.
Females were found at a higher risk of developing symptoms. Four SARS-CoV-2 waves were identified. Pharyngitis and rhinitis were more frequent during the fourth wave and among vaccinated subjects while cough, fever, flu syndrome, headache, anosmia, ageusia, arthralgia/arthritis and myalgia were more frequent during the first three waves and among unvaccinated subjects. A correlation was found between vaccination and the different waves in terms of developing pharyngitis and rhinitis.
Vaccination status and viruses' mutations had a synergic effect in the mitigation of the symptomatology caused by SARS-CoV-2 in healthcare workers.
自疫情开始以来，已识别出五种具有流行病学意义的变体，每种变体都有其症状表现模式和疾病严重程度。本研究的目的是分析疫苗接种状况在调节四波疫情期间与新冠病毒感染相关的症状表现模式中的作用。
利用医护人员监测活动的数据进行描述性分析、关联分析和多变量分析。对各波疫情期间疫苗接种状况和症状表现之间进行协同分析。
发现女性出现症状的风险更高。识别出了四波新冠病毒疫情。咽炎和鼻炎在第四波疫情期间以及接种疫苗的人群中更为常见，而咳嗽、发热、流感样综合征、头痛、嗅觉丧失、味觉丧失、关节痛/关节炎和肌痛在前三波疫情期间以及未接种疫苗的人群中更为常见。在咽炎和鼻炎的发生方面，发现疫苗接种与不同波次之间存在相关性。
疫苗接种状况和病毒突变在减轻医护人员中由新冠病毒引起的症状方面具有协同作用。
