Alder S, Candrian R, Elsner J, Zbinden G
Methods Find Exp Clin Pharmacol. 1986 May;8(5):279-89.
The usefulness of a neurobehavioral check-list for the detection and characterization of neurotoxic effects of chemical compounds was evaluated in rats. The animals were given single doses of the test compounds, and higher or lower doses of the substances were administered in subsequent weeks, depending on the outcome of the experiments. The testing procedure proved to be useful for detecting the neurobehavioral hazards of psychotherapeutics and other drugs with known neurobehavioral side-effects. However, the investigational technique was less satisfactory for evaluating alcohols and various neurotoxic agents. With these compounds, even repeated dosing did not improve the predictability of the testing scheme. Swimming performance was also investigated and was found to be impaired only in rats treated with neuroleptic drugs. Based on this validation study, the advantages and pitfalls of the neurobehavioral check-list approach are discussed.
在大鼠身上评估了神经行为检查表对于检测和表征化合物神经毒性作用的实用性。给动物单次注射受试化合物，随后几周根据实验结果给予更高或更低剂量的该物质。测试程序被证明对于检测具有已知神经行为副作用的精神治疗药物和其他药物的神经行为危害是有用的。然而，该研究技术在评估酒精和各种神经毒性剂方面不太令人满意。对于这些化合物，即使重复给药也没有提高测试方案的可预测性。还研究了游泳表现，发现仅在用抗精神病药物治疗的大鼠中游泳表现受损。基于这项验证研究，讨论了神经行为检查表方法的优点和缺陷。
