Université Côte d'Azur, Inserm, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 660 Route des Lucioles, 06560, Valbonne, France.
Université Côte d'Azur, Inserm, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 660 Route des Lucioles, 06560, Valbonne, France.
Curr Opin Cell Biol. 2023 Jun;82:102172. doi: 10.1016/j.ceb.2023.102172. Epub 2023 May 26.
VAP-A is a major endoplasmic reticulum (ER) receptor that allows this organelle to engage numerous membrane contact sites with other organelles. One highly studied example is the formation of contact sites through VAP-A interaction with Oxysterol-binding protein (OSBP). This lipid transfer protein transports cholesterol from the ER to the trans-Golgi network owing to the counter-exchange of the phosphoinositide PI(4)P. In this review, we highlight recent studies that advance our understanding of the OSBP cycle and extend the model of lipid exchange to other cellular contexts and other physiological and pathological conditions.
VAP-A 是内质网 (ER) 的主要受体，允许该细胞器与其他细胞器形成许多膜接触位点。一个被广泛研究的例子是通过 VAP-A 与 Oxysterol-binding protein (OSBP) 的相互作用形成接触位点。这种脂质转运蛋白通过反式交换磷酸肌醇 PI(4)P 将胆固醇从内质网转运到反式高尔基体网络。在这篇综述中，我们强调了最近的研究进展，这些研究加深了我们对 OSBP 循环的理解，并将脂质交换模型扩展到其他细胞环境以及其他生理和病理条件。
