Rheumatology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Clin Exp Rheumatol. 2023 Jun;41(6):1292-1300. doi: 10.55563/clinexprheumatol/mdk7az. Epub 2023 May 26.
To investigate sleep quality in patients with fibromyalgia (FM) and to analyse the effect of sleep on FM symptoms and quality of life.
Patients with FM and healthy subjects were recruited to assess their sleep quality, and patients were further assessed for pain, fatigue, depression, psychological stress and quality of life. The patients were divided into a sleep disorder group as measured by the Pittsburgh Sleep Quality Index (PSQI score >7 points) and a group without sleep disorders (PSQI score ≤7 points). Linear regression analysis was used to explore the effect of sleep quality on FM pain controlling for sex and age, and the effect of sleep quality on FM fatigue, depression, psychological stress and quality of life controlling for sex, age and pain.
A total of 450 patients and 50 healthy subjects participated in the study. The number of FM patients with sleep disorders was significantly higher than that of healthy subjects (90% vs. 14%, p≤0.001). In addition to the number of pain sites, the levels of pain, fatigue, depression, stress symptoms and quality of life were significantly impaired in FM patients with sleep disorders (p<0.05). In terms of the effects on quality of life assessed with the 36-item short-form health survey, the decrease in mental health was more substantial than the decrease in physical health (B=-12.10 vs. B=-5.40).
Similar to FM patients in other countries and regions, a decrease in sleep quality is also the core symptom of FM patients in China and is significantly correlated with the severity of pain, fatigue, depression and stress symptoms and reduced quality of life, especially with regard to mental health, suggesting that the treatment of this disease should include sleep disorder interventions.
调查纤维肌痛（FM）患者的睡眠质量，并分析睡眠对 FM 症状和生活质量的影响。
招募 FM 患者和健康受试者以评估其睡眠质量，进一步评估患者的疼痛、疲劳、抑郁、心理压力和生活质量。根据匹兹堡睡眠质量指数（PSQI 评分>7 分）将患者分为睡眠障碍组和无睡眠障碍组（PSQI 评分≤7 分）。采用线性回归分析，在控制性别和年龄的情况下，探讨睡眠质量对 FM 疼痛的影响；在控制性别、年龄和疼痛的情况下，探讨睡眠质量对 FM 疲劳、抑郁、心理压力和生活质量的影响。
共有 450 名患者和 50 名健康受试者参与了研究。睡眠障碍 FM 患者的数量明显高于健康受试者（90%比 14%，p≤0.001）。除疼痛部位数量外，睡眠障碍 FM 患者的疼痛、疲劳、抑郁、压力症状和生活质量水平均明显受损（p<0.05）。在使用 36 项简短健康调查评估生活质量方面，心理健康下降的幅度大于身体健康下降的幅度（B=-12.10 比 B=-5.40）。
与其他国家和地区的 FM 患者一样，睡眠质量下降也是中国 FM 患者的核心症状，与疼痛、疲劳、抑郁和压力症状的严重程度以及生活质量的降低显著相关，尤其是心理健康方面，这表明该疾病的治疗应包括睡眠障碍干预。
