Prenatal Diagnosis Unit, Boai Hospital of Zhongshan, Zhongshan, Guangdong, People's Republic of China.
Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong, People's Republic of China.
Hemoglobin. 2023 Nov;47(2):102-104. doi: 10.1080/03630269.2023.2215445. Epub 2023 May 29.
We report three cases of fetalis hydrops associated with nondeletional α-thalassemia. Two cases were caused by hemoglobin (Hb) H-Quong Sz disease, and one caused by homozygous Hb Constant Spring. Fetal hydrops occurred in the late second trimester in all three cases. Our study indicates that for pregnancies at risk for fetal nondeletional Hb H disease, strict ultrasound follow-up is particularly important. Even without techniques of intrauterine transfusion treatment, early prenatal diagnosis can enable parents to make timely decisions.
我们报告了三例与非缺失型α-地中海贫血相关的胎儿水肿。两例由血红蛋白（Hb）H-Quong Sz 病引起，一例由纯合型 Hb Constant Spring 引起。三例均在妊娠晚期出现胎儿水肿。本研究表明，对于有胎儿非缺失型 Hb H 病风险的妊娠，严格的超声随访尤为重要。即使没有宫内输血治疗技术，早期产前诊断也可以使父母及时做出决定。
