Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia.
Asian Pac J Cancer Prev. 2023 May 1;24(5):1731-1735. doi: 10.31557/APJCP.2023.24.5.1731.
Our study aimed to characterize alteration in the immunohistochemical expression of estrogen, progesterone and androgen receptor in the tumour cells of primary pleomorphic adenomas and recurrent pleomorphic adenomas.
A retrospective study of data including 30 cases of primary pleomorphic adenomas (PA) without recurrences and 15 cases of recurrent pleomorphic adenomas were examined (RPA). RPA included 8 males and 7 females. Immunohistochemical expression of estrogen, progesterone and androgen receptor was examined in the selected cases. The percentage of slides was semi-quantitatively assessed by two independent observers and scores were given. The statistical analysis included the use of descriptive statistics and proportional frequencies.
AR expression was identified in 12 (40. %) out of 30 cases of (PA) pleomorphic adenomas and 7 of 15 cases recurrent pleomorphic adenomas (RPA) (46 %). The results showed that ER and PR expression were negative in PA and RPA.
Androgen receptors might have role in pathogenesis of PA and RPA. Estrogen and progesterone receptors have no role in development of recurrent pleomorphic salivary adenoma.
本研究旨在描述原发性多形性腺瘤和复发性多形性腺瘤肿瘤细胞中雌激素、孕激素和雄激素受体免疫组织化学表达的改变。
回顾性研究包括 30 例无复发的原发性多形性腺瘤（PA）和 15 例复发性多形性腺瘤（RPA）患者。RPA 包括 8 名男性和 7 名女性。对选定病例进行雌激素、孕激素和雄激素受体的免疫组织化学表达检测。两位独立观察者对幻灯片的百分比进行半定量评估并给出评分。统计分析包括使用描述性统计和比例频率。
在 30 例多形性腺瘤（PA）和 15 例复发性多形性腺瘤（RPA）中，有 12 例（40%）存在 AR 表达。结果显示，PA 和 RPA 中 ER 和 PR 表达均为阴性。
雄激素受体可能在 PA 和 RPA 的发病机制中起作用。雌激素和孕激素受体在复发性多形性腺瘤唾液腺瘤的发展中不起作用。
