No information is available on the clinical use of retifanlimab during breastfeeding. Because retifanlimab is a large protein molecule with a molecular weight of 148,000 Da, the amount in milk is likely to be very low. It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal. Waiting for at least 2 weeks postpartum to resume therapy may minimize transfer to the infant.[1] The manufacturer recommends avoiding breastfeeding during therapy and for 4 months after the last dose.
目前尚无关于瑞替凡利单抗在母乳喂养期间临床应用的信息。由于瑞替凡利单抗是一种分子量为148,000道尔顿的大蛋白质分子,乳汁中的含量可能非常低。它也可能在婴儿胃肠道中被部分破坏,婴儿的吸收可能微乎其微。产后至少等待2周再恢复治疗可能会将对婴儿的转移降至最低。[1]制造商建议在治疗期间及最后一剂后4个月内避免母乳喂养。