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新诊断为高血压的老年人中达到 NICE 血压目标:全国性电子健康记录队列研究。

Attainment of NICE blood pressure targets among older people with newly diagnosed hypertension: nationwide linked electronic health records cohort study.

机构信息

Academic Unit for Ageing and Stroke Research, University of Leeds, Leeds, England LS2 9LH, UK.

Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Bradford, England BD9 6RJ, UK.

出版信息

Age Ageing. 2023 May 1;52(5). doi: 10.1093/ageing/afad077.

Abstract

BACKGROUND

it is not known if clinical practice reflects guideline recommendations for the management of hypertension in older people and whether guideline adherence varies according to overall health status.

AIMS

to describe the proportion of older people attaining National Institute for Health and Care Excellence (NICE) guideline blood pressure targets within 1 year of hypertension diagnosis and determine predictors of target attainment.

METHODS

a nationwide cohort study of Welsh primary care data from the Secure Anonymised Information Linkage databank including patients aged ≥65 years newly diagnosed with hypertension between 1st June 2011 and 1st June 2016. The primary outcome was attainment of NICE guideline blood pressure targets as measured by the latest blood pressure recording up to 1 year after diagnosis. Predictors of target attainment were investigated using logistic regression.

RESULTS

there were 26,392 patients (55% women, median age 71 [IQR 68-77] years) included, of which 13,939 (52.8%) attained a target blood pressure within a median follow-up of 9 months. Success in attaining target blood pressure was associated with a history of atrial fibrillation (OR 1.26, 95% CI 1.11, 1.43), heart failure (OR 1.25, 95% CI 1.06, 1.49) and myocardial infarction (OR 1.20, 95% CI 1.10, 1.32), all compared to no history of each, respectively. Care home residence, the severity of frailty, and increasing co-morbidity were not associated with target attainment following adjustment for confounder variables.

CONCLUSIONS

blood pressure remains insufficiently controlled 1 year after diagnosis in nearly half of older people with newly diagnosed hypertension, but target attainment appears unrelated to baseline frailty, multi-morbidity or care home residence.

摘要

背景

目前尚不清楚临床实践是否反映了老年人高血压管理的指南建议,以及指南的依从性是否因整体健康状况而异。

目的

描述在高血压诊断后 1 年内达到英国国家卫生与保健优化研究所(NICE)指南血压目标的老年人比例,并确定目标达标率的预测因素。

方法

这是一项基于威尔士初级保健数据的全国性队列研究,数据来自 Secure Anonymised Information Linkage 数据库,包括 2011 年 6 月 1 日至 2016 年 6 月 1 日期间新诊断为高血压的年龄≥65 岁的患者。主要结局是通过诊断后 1 年内的最新血压记录测量达到 NICE 指南血压目标。使用逻辑回归来研究目标达标率的预测因素。

结果

共纳入 26392 例患者(55%为女性,中位年龄 71[IQR 68-77]岁),其中 13939 例(52.8%)在中位随访 9 个月内达到目标血压。成功达到目标血压与心房颤动史(OR 1.26,95%CI 1.11,1.43)、心力衰竭史(OR 1.25,95%CI 1.06,1.49)和心肌梗死史(OR 1.20,95%CI 1.10,1.32)相关,与无上述疾病史相比,差异均有统计学意义。在调整混杂因素后,养老院居住、虚弱严重程度和共病增多与目标达标无关。

结论

近一半新诊断为高血压的老年患者在诊断后 1 年内血压仍未得到充分控制,但目标达标率似乎与基线虚弱程度、多病共存或养老院居住无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a032/10226747/6d4dc5e7444a/afad077f1.jpg

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