Lincoln G A
J Endocrinol. 1979 Jan;80(1):133-40. doi: 10.1677/joe.0.0800133.
Adult Soay rams with low concentrations of gonadotrophins in the circulation as a result of 12 weeks of exposure to long daylengths (16 h light : 8 h darkness) were given small doses (100 ng) of synthetic luteinizing hormone releasing hormone (LH-RH) into the jugular vein two, four or seven times/day for 10 days. Each injection of LH-RH induced a transitory increase in the concentration of LH and testosterone in the plasma, whereas the concentration of FSH showed little immediate change. After repeated treatment with pulses of LH-RH, the responses of LH and testosterone became slightly enhanced and the plasma concentration of FSH became permanently raised; these changes were most conspicuous in the animals receiving the most frequent injections. At the end of the study when the injections of LH-RH were stopped, the concentrations of LH and testosterone remained low but the concentrations of FSH continued to be maintained at a high level for at least 24 h.
成年索艾羊由于暴露于长日照（16小时光照：8小时黑暗）12周，导致循环中促性腺激素浓度较低，每天两次、四次或七次经颈静脉给予小剂量（100纳克）的合成促黄体生成素释放激素（LH-RH），持续10天。每次注射LH-RH都会引起血浆中LH和睾酮浓度的短暂升高，而FSH浓度几乎没有立即变化。在用LH-RH脉冲反复治疗后，LH和睾酮的反应略有增强，FSH的血浆浓度永久性升高；这些变化在接受最频繁注射的动物中最为明显。在研究结束停止注射LH-RH时，LH和睾酮的浓度仍然较低，但FSH的浓度至少在24小时内持续维持在高水平。
