Department of Pediatrics, IMS & SUM Hospital, Bhubaneswar, 751003, Odisha, India.
Indian J Pediatr. 2024 Aug;91(8):842-844. doi: 10.1007/s12098-023-04612-x. Epub 2023 May 30.
Tumor-induced osteomalacia (TIO), a rare paraneoplastic syndrome is seen in association with the overproduction of fibroblast growth factor-23 (FGF-23) by certain mesenchymal tumors in adults. In children, these phosphaturic mesenchymal tumors produce features of rickets similar to TIO. This condition is characterized by elevated blood levels of FGF-23, low phosphate, low or normal active vitamin D, and high alkaline phosphatase. Though the removal of the tumor is curative; in cases where surgical resection is not possible, medical treatment is successful with phosphate and active vitamin D in the improvement of symptoms. The case of a child with features of rickets is presented here to illustrate the importance of identifying this rare condition and instituting appropriate intervention.
肿瘤相关性骨软化症（TIO）是一种罕见的副瘤综合征，与某些间叶肿瘤过度产生成纤维细胞生长因子 23（FGF-23）有关。在儿童中，这些磷酸尿性间叶肿瘤产生类似于 TIO 的佝偻病特征。这种情况的特点是血 FGF-23 水平升高，磷酸盐低，活性维生素 D 低或正常，碱性磷酸酶高。虽然肿瘤切除是治愈性的；但在无法进行手术切除的情况下，磷酸盐和活性维生素 D 的药物治疗可成功改善症状。本文报告了一例具有佝偻病特征的儿童病例，以说明识别这种罕见疾病并进行适当干预的重要性。
