International Center for Biomedicine (ICC), Santiago, Chile.
Laboratory of Neurosciences and Functional Medicine, Faculty of Science, University of Chile, Santiago, Chile.
J Alzheimers Dis. 2023;94(1):95-100. doi: 10.3233/JAD-230150.
Alzheimer's disease (AD) is the most common form of dementia in the elderly. AD is a multifactorial disease, affected by several factors including amyloid-β42 oligomers, self-assembled tau, microbiota molecules, etc. However, inflammatory components are critical to trigger AD. Neuroinflammatory pathology links glial activation by "damage signals" with tau hyperphosphorylation, as explained by the Neuroimmunomodulation Theory, discovered by the ICC laboratory. This theory elucidates the onset and progression of several degenerative diseases and concept of "multitarget" therapy. These studies led to the rationale to identify inflammatory targets for the action of bioactive molecules or drugs against AD.
阿尔茨海默病（AD）是老年人中最常见的痴呆症形式。AD 是一种多因素疾病，受多种因素影响，包括淀粉样β42 寡聚体、自组装的 tau、微生物组分子等。然而，炎症成分对于引发 AD 至关重要。神经炎症病理学通过神经免疫调节理论将“损伤信号”引起的神经胶质激活与 tau 过度磷酸化联系起来，该理论由 ICC 实验室发现。该理论阐明了几种退行性疾病的发病机制和“多靶点”治疗的概念。这些研究为识别针对 AD 的生物活性分子或药物作用的炎症靶点提供了依据。
