Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, GH Sergievsky Center, Columbia University, New York, NY, USA.
Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University, New York, NY, USA.
J Alzheimers Dis. 2023;93(3):991-994. doi: 10.3233/JAD-230346.
Periodontitis is a chronic inflammatory, bacterially-driven disease of the tooth-supporting tissues that shares several risk factors and elements of host response with Alzheimer's disease and related dementias (ADRD). Epidemiological studies have identified relatively consistent associations between adverse oral health conditions and ADRD. In this issue of the journal, a large study from the UK Biobank further explores these relationships along with MRI cognitive biomarkers. Despite its strength due to the large sample size, challenges in the study of periodontitis and neuroepidemiology markers include potential sampling bias, appropriate assessment of exposures, and the possibility of reverse causality.
牙周炎是一种慢性炎症性细菌驱动的牙齿支持组织疾病，它与阿尔茨海默病和相关痴呆症（ADRD）有几个共同的危险因素和宿主反应因素。流行病学研究已经确定了不良口腔健康状况与 ADRD 之间相对一致的关联。在本期杂志中，来自英国生物银行的一项大型研究进一步探讨了这些关系以及 MRI 认知生物标志物。尽管由于样本量大而具有优势，但牙周炎和神经流行病学标志物研究存在的挑战包括潜在的抽样偏差、暴露的适当评估以及反向因果关系的可能性。
