Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Department of Women's Health, Research Centre for Women's Health and University Women's Hospital of Tuebingen, University of Tuebingen, Tuebingen, Germany.
Gynecol Endocrinol. 2023 May 20;39(1):2216807. doi: 10.1080/09513590.2023.2216807.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that usually begins during adolescence. Patients may have severe metabolic disorders.
To investigate the levels of visfatin and apelin in adolescent girls with PCOS and to explore the importance of visfatin and apelin in glucose and lipid metabolism.
A total of 88 girls (aged 12-20 years) were prospectively and consecutively recruited during two years for the PCOS group ( = 44) and the control group ( = 44). Serum visfatin, apelin and other metabolic parameters were measured. Receiver operator characteristics (ROC) curve analysis was performed to reveal the diagnostic potential.
Visfatin, apelin and indicators of glucose and lipid-metabolism were not different for PCOS patients compared to control. However, insulin resistance (IR) in the PCOS-group was more frequent ( < 0.05). Visfatin in non-IR patients was higher than in IR-patients in the PCOS-group ( < 0.05). However, there was no difference in apelin levels between IR and non-IR patients in the PCOS-group ( > 0.05). ROC-curve analyses demonstrated that the optimal value of visfatin for predicting IR in PCOS-patients was 7.14 ng/mL, with 78.1% sensitivity and 68.7% specificity. In the PCOS-group, visfatin was positively correlated with high density lipoprotein cholesterol (HDL-C), and negatively correlated with HOMA-IR, apolipoprotein B (Apo-B), cholesterol (CHO), low density lipoprotein cholesterol (LDL-C) and CHO/HDL-C ratio ( < 0.05). Apelin had no correlation with all indices ( > 0.05).
Higher visfatin levels may prevent IR in adolescent PCOS patients, showing a positive predictive value for IR and also reflecting a beneficial effect on lipids. It is a possible protective factor at certain stages of metabolic syndrome.
多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，通常在青春期开始。患者可能有严重的代谢紊乱。
研究青春期多囊卵巢综合征（PCOS）患者中内脂素和 Apelin 的水平，并探讨内脂素和 Apelin 在糖脂代谢中的重要性。
前瞻性连续纳入两年间 88 例（年龄 12-20 岁）PCOS 患者（n=44）和对照组（n=44），测定血清内脂素、Apelin 及其他代谢参数。采用受试者工作特征（ROC）曲线分析揭示其诊断潜力。
与对照组相比，PCOS 患者的内脂素、Apelin 及糖脂代谢指标无差异，但 PCOS 组胰岛素抵抗（IR）更为常见（ < 0.05）。非 IR 患者的内脂素高于 PCOS 组的 IR 患者（ < 0.05）。然而，PCOS 组的 IR 与非 IR 患者的 Apelin 水平无差异（ > 0.05）。ROC 曲线分析表明，内脂素预测 PCOS 患者 IR 的最佳值为 7.14ng/ml，灵敏度为 78.1%，特异性为 68.7%。在 PCOS 组，内脂素与高密度脂蛋白胆固醇（HDL-C）呈正相关，与胰岛素抵抗指数（HOMA-IR）、载脂蛋白 B（Apo-B）、胆固醇（CHO）、低密度脂蛋白胆固醇（LDL-C）和 CHO/HDL-C 比值呈负相关（ < 0.05）。Apelin 与所有指标均无相关性（ > 0.05）。
较高的内脂素水平可能预防青春期 PCOS 患者的 IR，对 IR 具有阳性预测价值，也反映了对脂代谢的有益影响。在代谢综合征的某些阶段，它可能是一种保护因素。
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