Gümüş Ülker, Güzel Ali Irfan, Topcu Hasan Onur, Timur Hakan, Yılmaz Nafiye, Danışman Nuri
Zekai Tahir Burak Women's Health Education and Research Hospital, Hamamönü, Ankara, Turkey.
Zekai Tahir Burak Women's Health Education and Research Hospital, Hamamönü, Ankara, Turkey.
J Pediatr Adolesc Gynecol. 2015 Aug;28(4):249-53. doi: 10.1016/j.jpag.2014.08.007. Epub 2014 Aug 17.
We evaluated the plasma visfatin levels in hirsute female adolescents with polycystic ovary syndrome.
DESIGN, SETTING, AND PARTICIPANTS: This prospective case-control study included 87 female patients who were seen in our adolescence department. Demographic characteristics and hormonal and biochemical parameters were evaluated between patients with and without polycystic ovary syndrome. Next, we divided the patients with polycystic ovary syndrome into the following subgroups: overweight or obese (body mass index [BMI] ≥ 25 kg/m(2)) vs normal weight (BMI < 25 kg/m(2)) and hirsute vs nonhirsute.
There were statistically significant differences in the BMI, serum androgen levels, homeostasis model assessment-insulin resistance (HOMA-IR) levels, and insulin levels between patients with and without polycystic ovary syndrome (P < .05). The mean visfatin levels showed no statistically significant difference between these 2 groups (P > .05). The serum visfatin levels were similar between the 2 subgroups classified by BMI (P > .05). However, there were statistically significant differences in the total and free testosterone levels, 17-hydroxylase progesterone level, HOMA-IR level, and visfatin level between the 2 subgroups classified by hirsutism (P < .05). The plasma visfatin level was higher in hirsute PCOS than in nonhirsute PCOS patients.
Significantly higher visfatin levels were found in hirsute than in nonhirsute adolescents with PCOS. According to these results, plasma visfatin levels may be a useful marker in hirsute adolescents with PCOS.
我们评估了患有多囊卵巢综合征的多毛女性青少年的血浆内脂素水平。
设计、地点和参与者：这项前瞻性病例对照研究纳入了87名在我们青春期门诊就诊的女性患者。对患有和未患多囊卵巢综合征的患者的人口统计学特征以及激素和生化参数进行了评估。接下来，我们将多囊卵巢综合征患者分为以下亚组：超重或肥胖（体重指数[BMI]≥25kg/m²）与正常体重（BMI<25kg/m²）以及多毛与非多毛。
患有和未患多囊卵巢综合征的患者在BMI、血清雄激素水平、稳态模型评估胰岛素抵抗（HOMA-IR）水平和胰岛素水平方面存在统计学显著差异（P<.05）。这两组之间的平均内脂素水平无统计学显著差异（P>.05）。按BMI分类的两个亚组之间血清内脂素水平相似（P>.05）。然而，按多毛症分类的两个亚组之间在总睾酮和游离睾酮水平、17-羟孕酮水平、HOMA-IR水平和内脂素水平方面存在统计学显著差异（P<.05）。多毛型多囊卵巢综合征患者的血浆内脂素水平高于非多毛型多囊卵巢综合征患者。
发现多毛的多囊卵巢综合征青少年的内脂素水平显著高于非多毛的青少年。根据这些结果，血浆内脂素水平可能是多毛的多囊卵巢综合征青少年的一个有用标志物。
