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[铁死亡与药物性肝损伤]

[Ferroptosis and drug-induced liver injury].

作者信息

Li X B

机构信息

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2023 Apr 20;31(4):345-348. doi: 10.3760/cma.j.cn501113-20230403-00140.

Abstract

Ferroptosis is a type of regulated cell death driven by iron-dependent lipid peroxidation that has received extensive attention in recent years. A growing body of evidence suggests that ferroptosis contributes to the progression of drug-induced liver injury. Therefore, the role and mechanism of ferroptosis in the process of drug-induced liver injury deserve further extensive and in-depth exploration, which will aid in the discovery of novel biomarkers as well as the identification of potential approches of targeting ferroptosis to intervene in drug-induced liver injury.

摘要

铁死亡是一种由铁依赖性脂质过氧化驱动的程序性细胞死亡,近年来受到了广泛关注。越来越多的证据表明,铁死亡促成药物性肝损伤的进展。因此,铁死亡在药物性肝损伤过程中的作用和机制值得进一步广泛深入探索,这将有助于发现新的生物标志物以及确定靶向铁死亡干预药物性肝损伤的潜在方法。

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