Department of Gynecology and Obstetrics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Expert Rev Mol Diagn. 2023 Jul-Dec;23(7):635-642. doi: 10.1080/14737159.2023.2217331. Epub 2023 Jun 1.
To evaluate whether the fetal fraction of cell-free DNA at the first and second trimesters is associated with spontaneous preterm birth.
This was a retrospective cohort study with singleton pregnancies who underwent noninvasive prenatal testing. According to pregnancy outcome, eligible patients were divided into a delivery group ≥37 weeks of pregnancy (term group) and <37 weeks of pregnancy (spontaneous preterm group). Stepwise linear regression was used to identify maternal characteristics associated with the fetal fraction of cell-free DNA. Logistic regression analysis was performed to evaluate the association between the fetal fraction of cell-free DNA and spontaneous preterm birth, adjusted for confounding factors.
14,020 cases were included in the study, 13292 cases (94.81%) in the term group and 728 cases (5.19%) in the spontaneous preterm group. The cell-free fraction of fetal DNA was inversely correlated with maternal age and body mass index. Positively correlated with gestational age, fertility, and assisted reproductive technology. After adjusting for the covariates, logistic regression analysis revealed no statistically significant association between the fetal fraction of cell-free DNA and spontaneous preterm birth.
In our original study, we found no association between the fetal fraction on NIPT and subsequent spontaneous preterm birth.
评估胎儿游离 DNA 第一和第二 trimester 的胎儿分数与自发性早产之间是否存在关联。
这是一项回顾性队列研究，纳入了接受非侵入性产前检测的单胎妊娠患者。根据妊娠结局，将符合条件的患者分为分娩≥37 周（足月组）和<37 周（自发性早产组）。采用逐步线性回归确定与游离胎儿 DNA 胎儿分数相关的母体特征。采用 logistic 回归分析评估游离胎儿 DNA 胎儿分数与自发性早产之间的关系，并对混杂因素进行调整。
本研究共纳入 14020 例患者，其中 13292 例（94.81%）在足月组，728 例（5.19%）在自发性早产组。胎儿游离 DNA 分数与母亲年龄和体重指数呈负相关。与胎龄、生育力和辅助生殖技术呈正相关。在调整混杂因素后，logistic 回归分析显示，游离胎儿 DNA 分数与自发性早产之间无统计学关联。
在我们的原始研究中，我们未发现 NIPT 中的游离胎儿分数与随后的自发性早产之间存在关联。
