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美国华盛顿州金县对新冠疫情的法医监测

Medical Examiner Surveillance of the COVID-19 Pandemic in King County, Washington, USA.

作者信息

Harruff Richard C, De Silva Malintha, Lubin Micheline

机构信息

From the King County Medical Examiner's Office, Seattle, WA.

出版信息

Am J Forensic Med Pathol. 2023 Sep 1;44(3):157-165. doi: 10.1097/PAF.0000000000000839. Epub 2023 May 26.

Abstract

The King County Medical Examiner's Office in Seattle, Wash, initiated a surveillance project with a dedicated team and database tracking the spread of severe acute respiratory syndrome coronavirus 2, deaths due to coronavirus disease 2019 (COVID-19), and deaths occurring within 28 days of COVID-19 vaccination. From January 2020 through July 2022, the results of 13,801 nasal/nasopharyngeal swabs from 7606 decedents tested for the virus were assembled in the surveillance database. Generally, 2 samples were collected and tested separately by 2 different laboratories. Positive rates increased from 5.7% in 2020 to 14.3% in 2022. Of 744 decedents positive for the virus, autopsies were performed on 418 (56%); of these, 106 (25%) died of COVID-19 as either the primary or a contributing cause. Comparison of autopsy findings of those dying of COVID-19 with those positive for the virus but dying of other causes demonstrated increased risk for those with preexisting conditions. Of 1035 deaths reported within 28 days of vaccination, the rates of thrombotic complications and myocarditis were no higher than in other decedents. This study provides evidence of the value to public health surveillance of an adequately resourced medical examiner office in tracking viral spread in the community, understanding disease mortality, and assessing vaccine safety.

摘要

华盛顿州西雅图市金县法医办公室启动了一项监测项目,该项目有一个专门的团队和数据库,用于追踪严重急性呼吸综合征冠状病毒2的传播、2019冠状病毒病(COVID-19)导致的死亡以及在COVID-19疫苗接种后28天内发生的死亡。从2020年1月到2022年7月,对7606名死者的13801份鼻拭子/鼻咽拭子进行病毒检测的结果被汇总到监测数据库中。一般来说,2份样本由2个不同的实验室分别收集和检测。阳性率从2020年的5.7%上升到2022年的14.3%。在744名病毒检测呈阳性的死者中,418人(56%)进行了尸检;其中,106人(25%)死于COVID-19,为主要死因或次要死因。将死于COVID-19者的尸检结果与病毒检测呈阳性但死于其他原因者的尸检结果进行比较,发现有基础疾病者的风险增加。在接种疫苗后28天内报告的1035例死亡中,血栓并发症和心肌炎的发生率并不高于其他死者。这项研究证明了一个资源充足的法医办公室对公共卫生监测在追踪社区病毒传播、了解疾病死亡率和评估疫苗安全性方面的价值。

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