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Current Topics in the Management of Acute Traumatic Spinal Cord Injury.急性创伤性脊髓损伤的治疗进展。
Neurocrit Care. 2019 Apr;30(2):261-271. doi: 10.1007/s12028-018-0537-5.
3
Traumatic Spinal Cord Injury.创伤性脊髓损伤
Continuum (Minneap Minn). 2018 Apr;24(2, Spinal Cord Disorders):551-566. doi: 10.1212/CON.0000000000000581.
4
A Clinical Practice Guideline for the Management of Acute Spinal Cord Injury: Introduction, Rationale, and Scope.《急性脊髓损伤管理临床实践指南:引言、原理及范围》
Global Spine J. 2017 Sep;7(3 Suppl):84S-94S. doi: 10.1177/2192568217703387. Epub 2017 Sep 5.
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A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Use of Methylprednisolone Sodium Succinate.急性脊髓损伤患者管理临床实践指南:关于使用琥珀酸甲泼尼龙的建议
Global Spine J. 2017 Sep;7(3 Suppl):203S-211S. doi: 10.1177/2192568217703085. Epub 2017 Sep 5.
6
Management of acute traumatic spinal cord injuries.急性创伤性脊髓损伤的管理
Handb Clin Neurol. 2017;140:275-298. doi: 10.1016/B978-0-444-63600-3.00015-5.
7
Steroid Use for Acute Spinal Cord Injury in Latin America: A Potentially Dangerous Practice Guided by Fear of Lawsuit.拉丁美洲急性脊髓损伤使用类固醇:一种受诉讼恐惧驱使的潜在危险做法。
World Neurosurg. 2016 Apr;88:342-349. doi: 10.1016/j.wneu.2015.12.045. Epub 2015 Dec 28.
8
Methylprednisolone for the Treatment of Patients with Acute Spinal Cord Injuries: A Propensity Score-Matched Cohort Study from a Canadian Multi-Center Spinal Cord Injury Registry.甲基强的松龙治疗急性脊髓损伤患者:一项来自加拿大多中心脊髓损伤登记处的倾向评分匹配队列研究。
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Methylprednisolone for the treatment of acute spinal cord injury: point.甲泼尼龙用于治疗急性脊髓损伤:观点。
Neurosurgery. 2014 Aug;61 Suppl 1:32-5. doi: 10.1227/NEU.0000000000000393.
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Pharmacological therapy for acute spinal cord injury.急性脊髓损伤的药物治疗
Neurosurgery. 2013 Mar;72 Suppl 2:93-105. doi: 10.1227/NEU.0b013e31827765c6.

急性脊髓损伤的治疗:伊比利亚拉丁美洲脊柱外科医生的一项调查——第1部分:大剂量皮质类固醇的使用

Treatment of Acute Spinal Cord Injuries: A Survey Among Iberolatinoamerican Spine Surgeons - Part 1: Use of High-Dose Corticosteroids.

作者信息

Ribau Ana, Alves Jorge, Rodrigues-Pinto Ricardo

机构信息

Departamento de Ortopedia e Traumatologia, Centro Hospitalar e Universitário do Porto, Porto, Portugal.

Departamento de Ortopedia e Traumatologia do Centro Hospitalar Tâmega e Sousa, Penafiel, Portugal.

出版信息

Rev Bras Ortop (Sao Paulo). 2022 Aug 2;58(2):331-336. doi: 10.1055/s-0042-1749414. eCollection 2023 Apr.

DOI:10.1055/s-0042-1749414
PMID:37252297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10212641/
Abstract

The aim of the present study was to evaluate the current practice of using of methylprednisolone sodium succinate (MPSS) in acute spinal cord Injuries (ASCIs) among spine surgeons from Iberolatinoamerican countries.  A descriptive cross-sectional study design as a survey was conducted. A questionnaire composed of 2 sections, one on demographic data regarding the surgeons and MPSS administration, was sent by email to members of the Sociedad Ibero Latinoamericana de Columna (SILACO, in the Spanish acronym) and associated societies.  A total of 182 surgeons participated in the study: 65.4% (119) orthopedic surgeons and 24.6% (63) neurosurgeons. Sixty-nine (37.9%) used MPSS in the initial management of ASCIs. There were no significant differences between countries (  = 0.451), specialty (  = 0.352), or surgeon seniority (  = 0.652) for the use of corticosteroids in the initial management of ASCIs. Forty-five (65.2%) respondents reported using an initial high-dose bolus (30 mg/Kg) followed by a perfusion (5.4 mg/kg/h). Forty-six (66.7%) surgeons who used MPSS only prescribed it if the patients presented within 8 hours of the ASCI. Most of the surgeons (50.7% [35]) administered high-dose corticosteroids because of the conviction that it has clinal benefits and improves neurological recovery.  Results from the present survey show that MPSS use in ASCI is not widespread within spine surgeons and that the controversy regarding its use remains unresolved. This is probably due to the low level of evidence of the available data, to variations over the years, to inconsistencies in acute care protocols, and to health service pathways.

摘要

本研究旨在评估伊比利亚拉丁美洲国家脊柱外科医生在急性脊髓损伤(ASCI)中使用琥珀酸钠甲泼尼龙(MPSS)的当前实践情况。

开展了一项描述性横断面研究设计的调查。一份由2部分组成的问卷,一部分是关于外科医生和MPSS给药的人口统计学数据,通过电子邮件发送给伊比利亚拉丁美洲脊柱协会(SILACO,西班牙语首字母缩写)及相关协会的成员。

共有182名外科医生参与了该研究:65.4%(119名)骨科医生和24.6%(63名)神经外科医生。69名(37.9%)在ASCI的初始治疗中使用了MPSS。在ASCI初始治疗中使用皮质类固醇方面,国家(P = 0.451)、专业(P = 0.352)或外科医生资历(P = 0.652)之间没有显著差异。45名(65.2%)受访者报告使用初始大剂量推注(30mg/Kg),随后进行灌注(5.4mg/kg/h)。46名(66.7%)使用MPSS的外科医生仅在患者在ASCI后8小时内就诊时才开具该药。大多数外科医生(50.7%[35名])给予大剂量皮质类固醇是因为坚信其具有临床益处并能改善神经恢复。

本次调查结果表明,MPSS在脊柱外科医生中用于ASCI的情况并不普遍,关于其使用的争议仍未解决。这可能是由于现有数据的证据水平较低、多年来的变化、急性护理方案的不一致以及卫生服务途径等原因。