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迷雾之肺:一例肺泡蛋白沉积症病例报告

The Foggy Lungs: A Case Report on Pulmonary Alveolar Proteinosis.

作者信息

Paidi Gokul, Brar Jugroop S, Vizcaino Duran Andrea S, Benero-Fossatti Jose, Brar Anhad, Aziz Greye Farrah P

机构信息

Pulmonary and Critical Care Medicine, Arizona Lung, Sleep and Valley Fever Institute, Surprise, USA.

Medical Surgery, Universidad Autonoma de Guadalajara, Guadalajara, MEX.

出版信息

Cureus. 2023 Apr 26;15(4):e38150. doi: 10.7759/cureus.38150. eCollection 2023 Apr.

Abstract

Pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease characterized by macrophage dysfunction leading to the accumulation of surfactant in the alveoli and bronchiolar spaces, leading to impaired gas exchange and severe hypoxemia. The underlying mechanisms of PAP are not fully understood, but it is believed to involve impaired clearance of surfactant and abnormal immune responses. Diagnosis of PAP typically involves imaging studies and bronchoscopy, and treatment options include whole-lung lavage, pharmacotherapy, and lung transplantation. We report PAP in a 56-year-old female who worked in a dental office and had no prior diagnosis of lung disease.

摘要

肺泡蛋白沉积症(PAP)是一种罕见的间质性肺病,其特征为巨噬细胞功能障碍,导致表面活性物质在肺泡和细支气管腔内蓄积,进而引起气体交换受损和严重低氧血症。PAP的潜在机制尚未完全明确,但据信与表面活性物质清除受损及异常免疫反应有关。PAP的诊断通常涉及影像学检查和支气管镜检查,治疗选择包括全肺灌洗、药物治疗和肺移植。我们报告了一例56岁女性的PAP病例,该女性在牙科诊所工作,既往无肺部疾病诊断史。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f3e/10215024/2e41c036ed59/cureus-0015-00000038150-i01.jpg

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