Department of Rheumatology, Fujian Provincial Hospital, Fuzhou, China.
Fujian Medical University Provincial Clinical Medical College, Fuzhou, China.
DNA Cell Biol. 2023 Jul;42(7):358-363. doi: 10.1089/dna.2022.0636. Epub 2023 May 30.
Morphological changes of podocyte mitochondria are observed in patients with mitochondrial cytopathy and nephrotic syndrome. However, whether mitochondrial dynamics involved in podocyte in lupus nephritis (LN) is still not clear. This study aims to investigate the associations between mitochondrial morphology and podocyte lesions and laboratory and pathological features in LN. The foot process width (FPW) and mitochondrial morphology were observed through electron microscope. Then the associations between mitochondrial morphology and podocyte lesions and laboratory features were explored in various International Society of Nephrology/Renal Pathology Society class LN patients. Foot process effacement and excessive mitochondria fission in podocyte were observed and proteinuria was positively correlated with FPW. Mitochondria area, circumference, and aspect ratio were negatively correlated with BUN, and 24h-UTP positively correlated with Alb. At the same time, Alb was negatively correlated with form factor. FPW, form factor, surface density, and numerical density on area were positively correlated with 24h-UTP. Excessive mitochondrial fission is associated with podocyte damage and proteinuria, whereas the mechanism still needs to be explored.
在患有线粒体细胞病和肾病综合征的患者中观察到足细胞线粒体的形态变化。然而，线粒体动力学是否参与狼疮性肾炎 (LN) 中的足细胞仍不清楚。本研究旨在探讨 LN 患者中足细胞病变与实验室和病理特征之间的线粒体形态之间的关系。通过电子显微镜观察足突宽度 (FPW) 和线粒体形态。然后，在各种国际肾脏病学会/肾脏病理学会 LN 患者中探讨了线粒体形态与足细胞病变和实验室特征之间的关系。观察到足细胞的足突消失和线粒体过度分裂，蛋白尿与 FPW 呈正相关。线粒体面积、周长和纵横比与 BUN 呈负相关，24h-UTP 与 Alb 呈正相关。同时，Alb 与形态因子呈负相关。FPW、形态因子、面积表面密度和数值密度与 24h-UTP 呈正相关。过度的线粒体分裂与足细胞损伤和蛋白尿有关，但其机制仍需进一步探讨。
