Department of Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China.
Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, China.
ACS Nano. 2023 Jun 13;17(11):10560-10576. doi: 10.1021/acsnano.3c01502. Epub 2023 May 30.
The increasing applications of ionizing radiation in society raise the risk of radiation-induced intestinal and whole-body injury. Astaxanthin is a powerful antioxidant to reduce the reactive oxygen generated from radiation and the subsequent damage. However, the oral administration of astaxanthin remains challenging owing to its low solubility and poor bioavailability. Herein, we facilely construct an orally used microalgae-nano integrated system (SP@ASXnano) against radiation-induced intestinal and whole-body injury, combining natural microalgae (SP) with astaxanthin nanoparticles (ASXnano). SP and ASXnano show complementation in drug delivery to improve distribution in the intestine and blood. SP displays limited gastric drug loss, prolonged intestinal retention, constant ASXnano release, and progressive degradation. ASXnano improves drug solubility, gastric stability, cell uptake, and intestinal absorption. SP and ASXnano have synergy in many aspects such as anti-inflammation, microbiota protection, and fecal short-chain fatty acid up-regulation. In addition, the system is ensured with biosafety for long-term administration. The system organically combines the properties of microalgae and nanoparticles, which was expected to expand the medical application of SP as a versatile drug delivery platform.
电离辐射在社会中的应用日益广泛，增加了辐射诱导的肠道和全身损伤的风险。虾青素是一种强大的抗氧化剂，可以减少辐射产生的活性氧和随后的损伤。然而，由于其低溶解度和差的生物利用度，虾青素的口服给药仍然具有挑战性。在此，我们通过将天然微藻 (SP) 与虾青素纳米颗粒 (ASXnano) 结合，简便地构建了一种用于辐射诱导的肠道和全身损伤的口服使用的微藻-纳米综合系统 (SP@ASXnano)。SP 和 ASXnano 在药物递送上具有互补性，以改善在肠道和血液中的分布。SP 表现出有限的胃药物损失、延长的肠道保留、恒定的 ASXnano 释放和渐进的降解。ASXnano 提高了药物的溶解度、胃稳定性、细胞摄取和肠道吸收。SP 和 ASXnano 在抗炎、微生物群保护和粪便短链脂肪酸上调等多个方面具有协同作用。此外，该系统具有长期给药的生物安全性。该系统有机地结合了微藻和纳米颗粒的特性，有望扩大 SP 作为多功能药物递送平台的医学应用。
