Walterspiel J N, Kaplan S L
Pediatr Infect Dis. 1986 May-Jun;5(3):328-32. doi: 10.1097/00006454-198605000-00011.
Sixty episodes of infective endocarditis were analyzed in 56 pediatric patients over a 10-year period from 1974 to 1984. Culture-negative infective endocarditis was noted on five occasions or 8.3% of all episodes. In addition to the physical findings, a combination of laboratory parameters including anemia, erythrocyte sedimentation rate, elevated rheumatoid factor, C1q activation and microhematuria supported the diagnosis. The clinical characteristics of these patients are described in detail. Pretreatment with an antimicrobial agent was only one factor associated with the failure to isolate an organism. Empiric treatment with penicillin and gentamicin and in one case nafcillin/ampicillin and gentamicin was satisfactory.
在1974年至1984年的10年期间，对56名儿科患者的60例感染性心内膜炎进行了分析。有5例（占所有病例的8.3%）出现了血培养阴性的感染性心内膜炎。除了体格检查结果外，包括贫血、红细胞沉降率、类风湿因子升高、C1q激活和微量血尿在内的一系列实验室指标也支持该诊断。详细描述了这些患者的临床特征。抗菌药物的预处理只是与未能分离出病原体相关的一个因素。青霉素和庆大霉素的经验性治疗，以及1例使用萘夫西林/氨苄西林和庆大霉素的治疗效果令人满意。
