Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Eur Thyroid J. 2023 Jul 12;12(4):e230051. doi: 10.1530/ETJ-23-0051.
A decrease in the use of radioactive iodine (RAI) treatment for thyroid cancer has been described in the last decade in the US following subsequent updates of the American Thyroid Association guidelines. By contrast, population-based data from European countries are lacking. The study aims to assess the frequency and long-term trends in the use of RAI in Italy.
From the Italian national hospital discharge database, the proportion of RAI treatment after total thyroidectomy with thyroid cancer diagnosis has been assessed by sex and age class during 2001-2018.
Throughout the whole study period, RAI was performed after 58% of 149,419 total thyroidectomies. The use of RAI was higher for men and younger patients; it peaked in 2007 (64% in women and 68% in men) and declined thereafter (2018: 46% in women and 53% in men), with a similar pattern observed across all ages and areas.
National data show that in Italy trends in RAI treatment paraleled those observed in the US. Further monitoring of the use of RAI is warranted in Italy, as elsewhere, to assess the impact of international guidelines on real-life clinical management of thyroid cancer.
在美国，自美国甲状腺协会指南更新后，近十年来，放射性碘（RAI）治疗甲状腺癌的应用有所减少。相比之下，欧洲国家缺乏基于人群的数据。本研究旨在评估意大利 RAI 的应用频率和长期趋势。
从意大利国家住院数据库中，评估了 2001 年至 2018 年间甲状腺癌诊断后行全甲状腺切除术患者中，按性别和年龄组分类接受 RAI 治疗的比例。
在整个研究期间，有 58%的 149419 例全甲状腺切除术患者接受了 RAI 治疗。男性和年轻患者的 RAI 使用率较高；2007 年达到峰值（女性 64%，男性 68%），此后逐渐下降（2018 年：女性 46%，男性 53%），各年龄段和地区均呈现类似的模式。
国家数据显示，意大利 RAI 治疗趋势与美国观察到的趋势一致。与其他地方一样，意大利也需要进一步监测 RAI 的使用情况，以评估国际指南对甲状腺癌实际临床管理的影响。
