Neonatal Intensive Care Unit, Department of Woman's and Child's Health, Azienda Ospedale-Università di Padova, Italy; Institute of Pediatric Research "Città Della Speranza", Padova, Italy.
Department of Neuroradiology, Azienda Ospedale-Università di Padova, Italy.
EBioMedicine. 2023 Jun;92:104636. doi: 10.1016/j.ebiom.2023.104636. Epub 2023 May 29.
The pathobiological mechanisms associated with perinatal asphyxia and hypoxic-ischemic encephalopathy are complex and poorly understood. The metabolic effects of therapeutic hypothermia have been partially explored.
We conducted a single-center longitudinal study to investigate the metabolic effects of perinatal asphyxia and hypoxic-ischemic encephalopathy on the urinary metabolome of a group of 12 asphyctic infants over time compared to 22 matched healthy newborns, using untargeted metabolomics based on mass spectrometry.
Over-representation pathway analysis identified the steroidogenesis pathway as being significantly disrupted, with reduced steroid levels in the first three days of life despite treatment with hypothermia. Comparison with matched healthy newborns showed that the urinary steroid content was lower in asphyctic infants before hypothermia. The lysine degradation and carnitine synthesis pathways were also significantly affected.
Steroidogenesis is significantly disrupted in asphyctic infants compared to healthy newborns. Given how neurosteroids are involved in neuromodulation and neuroprotection, translational research is warranted on the potential role of neurosteroid-based intervention in asphyctic infants.
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与围产期窒息和缺氧缺血性脑病相关的病理生物学机制复杂且尚未被充分了解。治疗性低温的代谢效应已部分被探索。
我们进行了一项单中心纵向研究，旨在通过基于质谱的非靶向代谢组学，比较 12 例窒息婴儿与 22 例匹配的健康新生儿随时间推移的尿液代谢组，来研究围产期窒息和缺氧缺血性脑病对代谢组的影响。
过度表达途径分析确定了类固醇生成途径明显受到干扰，尽管进行了低温治疗，但在生命的头三天类固醇水平仍降低。与匹配的健康新生儿相比，在进行低温治疗之前，窒息婴儿的尿类固醇含量较低。赖氨酸降解和肉碱合成途径也受到明显影响。
与健康新生儿相比，窒息婴儿的类固醇生成明显受到干扰。鉴于神经甾体在神经调节和神经保护中的作用，有必要对神经甾体为基础的干预措施在窒息婴儿中的潜在作用进行转化研究。
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