高危脂肪肉瘤中 perilipin 1 和 adipophilin 的免疫组织化学表达的预后意义。

Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma.

机构信息

Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan.

Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan.

出版信息

J Clin Pathol. 2024 Sep 19;77(10):676-682. doi: 10.1136/jcp-2023-208814.

DOI:10.1136/jcp-2023-208814

PMID:37258253

Abstract

AIMS

Liposarcoma is a malignant soft tissue tumour with adipocytic differentiation. Dedifferentiated liposarcoma (DDLS) and myxoid liposarcoma (MLS) are classified as high-grade liposarcomas. Lipid droplet-associated protein (also known as perilipin 1 (PLIN1)) is the predominant perilipin and has utility as a specific marker of adipogenic differentiation. Adipose differentiation-related protein (also known as adipophilin (ADRP)) is ubiquitously expressed in a range of tissues. High ADRP expression is reportedly a poor prognostic factor in several cancer types. However, no previous studies have examined the association between PLIN1 or ADRP expression and prognosis in sarcoma. This study therefore aimed to evaluate the association between PLIN1 or ADRP expression and prognosis in liposarcoma.

METHODS

In total, 97 primary resection specimens (53 MLS and 44 DDLS) were examined in this study. PLIN1 and ADRP expression was evaluated by immunohistochemistry. Survival analyses were performed for MLS and DDLS.

RESULTS

Of the 53 MLS specimens, 15 (28.3%) exhibited high PLIN1 expression. PLIN1 expression was not observed in DDLS specimens. High PLIN1 expression was significantly associated with increased disease-free survival (DFS) among patients with MLS (p=0.045). Distinct ADRP expression was observed in 13 of 53 (24.5%) MLS specimens and 5 of 44 (11.4%) DDLS specimens. High ADRP expression was associated with shorter overall survival (OS) in MLS (p=0.042) and DFS and shorter OS in DDLS (p=0.024 and p<0.001, respectively).

CONCLUSIONS

PLIN1 and ADRP expression is associated with poor prognosis in high-grade liposarcoma.

摘要

目的

脂肪肉瘤是一种具有脂肪分化的恶性软组织肿瘤。去分化脂肪肉瘤（DDLS）和黏液样脂肪肉瘤（MLS）被归类为高级别脂肪肉瘤。脂滴相关蛋白（也称为 perilipin 1（PLIN1））是主要的 perilipin，可用作脂肪生成分化的特异性标志物。脂肪分化相关蛋白（也称为 adipophilin（ADRP））在多种组织中广泛表达。据报道，ADRP 高表达是几种癌症类型的不良预后因素。然而，以前的研究尚未检查 PLIN1 或 ADRP 表达与肉瘤预后之间的关系。因此，本研究旨在评估 PLIN1 或 ADRP 表达与脂肪肉瘤预后之间的关系。

方法

本研究共检查了 97 例原发性切除标本（53 例 MLS 和 44 例 DDLS）。通过免疫组织化学评估 PLIN1 和 ADRP 的表达。对 MLS 和 DDLS 进行生存分析。

结果

在 53 例 MLS 标本中，有 15 例（28.3%）表现出高 PLIN1 表达。DDLS 标本中未观察到 PLIN1 表达。高 PLIN1 表达与 MLS 患者无复发生存（DFS）显著相关（p=0.045）。在 53 例 MLS 标本中有 13 例（24.5%）和 44 例 DDLS 标本中有 5 例（11.4%）观察到明显的 ADRP 表达。高 ADRP 表达与 MLS 的总生存（OS）和 DFS 较短相关（p=0.042）和 DDLS 的 OS 较短（p=0.024 和 p<0.001）。