Voigt R, Wunsch G
Pharmazie. 1986 Feb;41(2):114-7.
The influence of the thickness of polymer films on drug release was studied by means of an apparatus, developed especially for the examination of film-coated pellets. To show the direct dependence of the thickness of the polymer layer on the process of liberation a sequence of ten coating steps was chosen. On the contrary the release of active ingredients of varying dissolution behaviour was synchronous and didn't depend on the pH-value of the medium. The results show, that by using the proper coating material the thickness of the layer can be used to control the drug liberation process. The comparison of the release from different coating steps in the apparatus described makes it possible to produce mixtures of pellets with both a quick onset and a long duration of action by using only one type of coating material.
通过一种专门开发用于检测薄膜包衣微丸的仪器，研究了聚合物薄膜厚度对药物释放的影响。为了表明聚合物层厚度与释放过程的直接相关性，选择了十个包衣步骤的序列。相反，具有不同溶解行为的活性成分的释放是同步的，并且不依赖于介质的pH值。结果表明，通过使用合适的包衣材料，层的厚度可用于控制药物释放过程。在所描述的仪器中比较不同包衣步骤的释放情况，使得仅使用一种包衣材料就可以生产出具有快速起效和长效作用的微丸混合物。
