Sturdíková M, Fuska J, Grossmann E, Votický Z
Pharmazie. 1986 Apr;41(4):270-2.
Vincaminorine and vincaminoreine, the monomeric indole alkaloids, belonging to the respective quebrachamine skeletal types, and vincadifformine of the aspidospermine group were those of 15 bases examined found to exhibit a considerable inhibition effect on the P388 cells. The above-mentioned secondary metabolites inhibited the synthesis of nucleic acids and proteins. Vincadifformine, which was found to inhibit most significantly the biochemical functions of P388 cells of all monomers under study, stopped the proliferation of cells in vitro in a 50 micrograms X ml-1 concentration even after 12 h of action. The effect of vincadifformine was greater than that of vinblastine, which was evaluated under the same conditions on the P388 cells in vitro.
长春米诺林和长春米诺赖因这两种单体吲哚生物碱，分别属于育亨宾骨架类型，以及阿朴菲类的长春地辛，在所检测的15种碱基中，它们对P388细胞表现出相当大的抑制作用。上述次生代谢产物抑制核酸和蛋白质的合成。长春地辛在所有研究的单体中对P388细胞的生化功能抑制最为显著，即使在作用12小时后，其50微克/毫升的浓度也能使体外细胞增殖停止。长春地辛的作用大于长春碱，后者是在相同条件下对体外P388细胞进行评估的。
