Wilkoff L J, Dulmadge E A
J Natl Cancer Inst. 1982 Jun;68(6):1023-6.
Cultured P388 leukemia cells derived from vincristine (VCR)-resistant cell populations developed in vivo in (C57BL X DBA/2)F1 mice (P388/VCR) were cross-resistant to vinblastine (VLB), vindesine (VDS), and bis(N-ethylidene vindesine)disulfide, disulfate (bis-VDS). Cross-resistance was a function of concentration and time of exposure. Cultured P388/VCR cells were more sensitive to 6.1x10-5Mbis- VDS than to 6.1x10-5MVDS or to 6.1x10-5MVLB. Cultured P388 cells derived from VCR-sensitive P388 leukemia passaged in vivo (P388/0)were significantly more sensitive to VDS and bis-VDS than to VLB. This degree of difference in sensitivity was also a function of concentration and time of exposure.
从在（C57BL×DBA/2）F1小鼠体内产生的长春新碱（VCR）耐药细胞群体中获得的培养P388白血病细胞（P388/VCR）对长春花碱（VLB）、长春地辛（VDS）和双（N - 亚乙基长春地辛）二硫化物二硫酸盐（双 - VDS）具有交叉耐药性。交叉耐药性是暴露浓度和时间的函数。培养的P388/VCR细胞对6.1×10⁻⁵M双 - VDS比6.1×10⁻⁵M VDS或6.1×10⁻⁵M VLB更敏感。从体内传代的VCR敏感P388白血病中获得的培养P388细胞（P388/0）对VDS和双 - VDS比VLB更敏感得多。这种敏感性差异程度也是暴露浓度和时间的函数。
