• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

在埃塞俄比亚实施六个月剂量抗逆转录病毒疗法:来自患者和医疗工作者的观点。

Implementing six multi-month dispensing of antiretroviral therapy in Ethiopia: perspectives of clients and healthcare workers.

机构信息

New York State Psychiatric Institute and Department of Psychiatry, HIV Center for Clinical and Behavioral Studies, Gender, Sexuality and Health Area, Columbia University Irving Medical Center, New York, New York, United States of America.

ICAP at Columbia University, New York, NY, United States of America.

出版信息

BMC Health Serv Res. 2023 May 31;23(1):563. doi: 10.1186/s12913-023-09549-7.

DOI:10.1186/s12913-023-09549-7
PMID:37259098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10231954/
Abstract

BACKGROUND

Multi-month dispensing (MMD) of antiretroviral therapy (ART) is an integral component of differentiated HIV service delivery for people living with HIV (PLHIV). Although many countries have scaled up ART dispensing to 3-month intervals, Ethiopia was the first African country to implement six-month dispensing (6-MMD) at scale, introducing its Appointment Spacing Model (ASM) for people doing well on ART in 2017. As of June 2021, 51.4% (n = 215,101) of PLHIV on ART aged ≥ 15 years had enrolled in ASM. Since little is known about the benefits and challenges of ASM perceived by Ethiopian clients and their healthcare workers (HCWs), we explored how the ASM was being implemented in Ethiopia's Oromia region in September 2019.

METHODS

Using a parallel convergent mixed-methods study design, we conducted 6 focus groups with ASM-eligible enrolled clients, 6 with ASM-eligible non-enrolled clients, and 22 in-depth interviews with HCWs. Data were audio-recorded, transcribed and translated into English. We used thematic analysis, initially coding deductively, followed by inductive coding of themes that emerged from the data, and compared the perspectives of ASM-enrolled and non-enrolled clients and their HCWs.

RESULTS

Participants enrolled in ASM and HCWs perceived client-level ASM benefits to include time and cost-savings, fewer work disruptions, reduced stigma due to fewer clinic visits, better medication adherence and improved overall health. Perceived health system-level benefits included improved quality of care, decongested facilities, reduced provider workloads, and improved record-keeping. Although non-enrolled participants anticipated many of the same benefits, their reasons for non-enrollment included medication storage challenges, concerns over less frequent health monitoring, and increased stress due to the large quantities of medicines dispensed. Enrolled participants and HCWs identified similar challenges, including client misunderstandings about ASM and initial ART stock-outs.

CONCLUSIONS

ASM with 6-MMD was perceived to have marked benefits for clients and health systems. Clients enrolled in the ASM and their HCWs had positive experiences with the model, including perceived improvements in efficiency, quality and convenience of HIV treatment services. The concerns of non-ASM enrolled participants suggest the need for enhanced client education about the model and more discreet and efficiently packaged ART and highlight that ASM is not ideal for all clients.

摘要

背景

抗逆转录病毒疗法(ART)的多(月)配药是为艾滋病毒感染者(PLHIV)提供差异化 HIV 服务的一个组成部分。尽管许多国家已经将 ART 配药延长至 3 个月的间隔,但埃塞俄比亚是第一个在大规模实施 6 个月配药(6-MMD)的非洲国家,它于 2017 年为在 ART 上表现良好的人推出了预约间隔模型(ASM)。截至 2021 年 6 月,51.4%(n=215101)年龄≥15 岁的接受 ART 治疗的 PLHIV 已注册 ASM。由于人们对埃塞俄比亚客户及其医疗保健工作者(HCW)感知到的 ASM 的好处和挑战知之甚少,我们在 2019 年 9 月探索了 ASM 在埃塞俄比亚奥罗米亚地区的实施情况。

方法

使用平行收敛混合方法研究设计,我们对符合 ASM 条件的注册客户进行了 6 次焦点小组讨论,对符合 ASM 条件的未注册客户进行了 6 次焦点小组讨论,对 HCW 进行了 22 次深入访谈。数据被录音、转录并翻译成英文。我们使用主题分析,最初进行演绎式编码,然后对数据中出现的主题进行归纳式编码,并比较了 ASM 注册客户和未注册客户及其 HCW 的观点。

结果

注册 ASM 的参与者和 HCW 认为客户层面 ASM 的好处包括节省时间和成本、减少工作中断、因就诊次数减少而减少耻辱感、更好地遵守药物治疗和改善整体健康。感知到的卫生系统层面的好处包括改善护理质量、设施不拥挤、减少提供者工作量以及改善记录保存。尽管未注册的参与者预计会有许多相同的好处,但他们不注册的原因包括药物储存困难、对较少的健康监测的担忧,以及因分发的药物数量增加而增加的压力。注册参与者和 HCW 发现了类似的挑战,包括客户对 ASM 的误解和初始 ART 库存不足。

结论

6-MMD 的 ASM 被认为对客户和卫生系统有显著的好处。注册 ASM 的客户及其 HCW 对该模型有积极的体验,包括认为艾滋病毒治疗服务的效率、质量和便利性有所提高。未注册 ASM 的参与者的担忧表明,需要加强对该模型的客户教育,并需要更谨慎和有效地包装 ART,并突出表明 ASM 并不适合所有客户。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf4/10233918/d9d12f09aba4/12913_2023_9549_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf4/10233918/d4f1e162a393/12913_2023_9549_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf4/10233918/200308ce855f/12913_2023_9549_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf4/10233918/d9d12f09aba4/12913_2023_9549_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf4/10233918/d4f1e162a393/12913_2023_9549_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf4/10233918/200308ce855f/12913_2023_9549_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cf4/10233918/d9d12f09aba4/12913_2023_9549_Fig3_HTML.jpg

相似文献

1
Implementing six multi-month dispensing of antiretroviral therapy in Ethiopia: perspectives of clients and healthcare workers.在埃塞俄比亚实施六个月剂量抗逆转录病毒疗法:来自患者和医疗工作者的观点。
BMC Health Serv Res. 2023 May 31;23(1):563. doi: 10.1186/s12913-023-09549-7.
2
A Qualitative Assessment of Provider and Client Experiences With 3- and 6-Month Dispensing Intervals of Antiretroviral Therapy in Malawi.马拉维抗逆转录病毒疗法 3 个月和 6 个月配药间隔的提供者和患者体验的定性评估。
Glob Health Sci Pract. 2020 Mar 31;8(1):18-27. doi: 10.9745/GHSP-D-19-00286. Print 2020 Mar 30.
3
Provider experiences with three- and six-month antiretroviral therapy dispensing for stable clients in Zambia.赞比亚为稳定的艾滋病病毒感染者提供三个月和六个月抗逆转录病毒疗法药物配给的经验。
AIDS Care. 2021 Apr;33(4):541-547. doi: 10.1080/09540121.2020.1755010. Epub 2020 May 4.
4
"We are part of a family". Benefits and limitations of community ART groups (CAGs) in Thyolo, Malawi: a qualitative study.我们是一个大家庭的一部分。马拉维蒂约洛社区 ART 小组(CAGs)的好处和局限性:一项定性研究。
J Int AIDS Soc. 2017 Mar 28;20(1):21374. doi: 10.7448/IAS.20.1.21374.
5
Client and provider preferences for HIV care: Implications for implementing differentiated service delivery in Thailand.患者和提供者对艾滋病毒护理的偏好:对在泰国实施差异化服务提供的影响。
J Int AIDS Soc. 2021 Apr;24(4):e25693. doi: 10.1002/jia2.25693.
6
Benefits and challenges of community-based multi-month dispensing of antiretroviral treatment in Zimbabwe: A qualitative study from a cluster randomized trial.津巴布韦基于社区的抗逆转录病毒治疗多月份配药的益处与挑战:一项整群随机试验的定性研究
Health Soc Care Community. 2022 Sep;30(5):e2838-e2848. doi: 10.1111/hsc.13727. Epub 2022 Jan 22.
7
'Only twice a year': a qualitative exploration of 6-month antiretroviral treatment refills in adherence clubs for people living with HIV in Khayelitsha, South Africa.“仅每年两次”:南非凯萨蒂沙艾滋病毒感染者依附治疗俱乐部中 6 个月抗逆转录病毒治疗药物的补充情况的定性研究。
BMJ Open. 2020 Jul 8;10(7):e037545. doi: 10.1136/bmjopen-2020-037545.
8
Healthcare worker perspectives on adaptations to differentiated anti-retroviral therapy delivery during COVID-19 in South Africa: A qualitative inquiry.南非医护人员对新冠疫情期间调整差异化抗逆转录病毒治疗给药方式的看法:一项定性研究。
PLOS Glob Public Health. 2024 Aug 9;4(8):e0003517. doi: 10.1371/journal.pgph.0003517. eCollection 2024.
9
Uptake and associated factors of six multi-month scripting/appointment spacing differentiated service delivery model of care among stable clients on antiretroviral therapy in Southern Ethiopia.埃塞俄比亚南部接受抗逆转录病毒治疗的稳定患者对六个月脚本/预约间隔区分服务提供模式的接受情况及其影响因素。
PLoS One. 2024 Sep 12;19(9):e0310400. doi: 10.1371/journal.pone.0310400. eCollection 2024.
10
The rollout of Community ART Refill Groups in Zimbabwe: a qualitative evaluation.津巴布韦社区 ART 续药组的推出:一项定性评估。
J Int AIDS Soc. 2019 Aug;22(8):e25393. doi: 10.1002/jia2.25393.

引用本文的文献

1
Appropriateness, barriers, and facilitators of multi-month dispensing of tuberculosis drugs in rural eastern Uganda: A qualitative study to inform a non-inferiority randomized trial.乌干达东部农村地区结核病药物多疗程配药的适宜性、障碍及促进因素:一项为非劣效性随机试验提供信息的定性研究
PLOS Glob Public Health. 2025 Sep 5;5(9):e0004539. doi: 10.1371/journal.pgph.0004539. eCollection 2025.
2
Health provider perspectives on differentiated service delivery for HIV in Oyo state, Nigeria: exploring the experiences of service providers from a demand perspective.尼日利亚奥约州医疗服务提供者对艾滋病差异化服务提供的看法:从需求角度探索服务提供者的经验
BMC Health Serv Res. 2025 Aug 21;25(1):1119. doi: 10.1186/s12913-025-13283-7.
3

本文引用的文献

1
Sample sizes for saturation in qualitative research: A systematic review of empirical tests.定性研究中饱和度的样本量:实证检验的系统综述。
Soc Sci Med. 2022 Jan;292:114523. doi: 10.1016/j.socscimed.2021.114523. Epub 2021 Nov 2.
2
Estimating the effect of increasing dispensing intervals on retention in care for people with HIV in Haiti.评估增加配药间隔时间对海地艾滋病毒感染者护理留存率的影响。
EClinicalMedicine. 2021 Jul 23;38:101039. doi: 10.1016/j.eclinm.2021.101039. eCollection 2021 Aug.
3
Patient volume and quality of primary care in Ethiopia: findings from the routine health information system and the 2014 Service Provision Assessment survey.
Scale of differentiated service delivery implementation in HIV care facilities in low- and middle-income countries: a global facility survey.
低收入和中等收入国家艾滋病护理机构差异化服务提供实施情况的规模:一项全球机构调查
J Int AIDS Soc. 2025 Jul;28 Suppl 3(Suppl 3):e26477. doi: 10.1002/jia2.26477.
4
Stakeholders' perspectives on the status of family planning integration into differentiated antiretroviral therapy service delivery models in Uganda: A qualitative assessment.利益相关者对乌干达将计划生育纳入差异化抗逆转录病毒治疗服务提供模式的现状的看法:一项定性评估。
PLoS One. 2025 May 22;20(5):e0324616. doi: 10.1371/journal.pone.0324616. eCollection 2025.
5
Evaluating the contribution of operation triple zero to HIV viral load suppression and retention among the adolescents in TASO Uganda using RE-AIM framework: a before and after implementation science study.运用RE-AIM框架评估乌干达艾滋病支持组织(TASO)开展的“三零行动”对青少年艾滋病毒载量抑制及留存率的贡献:一项实施前后的科学研究。
AIDS Res Ther. 2025 May 20;22(1):52. doi: 10.1186/s12981-025-00750-8.
6
Primary healthcare providers' perspectives on six-month dispensing of antiretroviral therapy (ART) in South Africa: cross-sectional survey of views and preferences.南非基层医疗服务提供者对六个月抗逆转录病毒疗法(ART)配药的看法:观点与偏好的横断面调查
Glob Health Action. 2025 Dec;18(1):2484111. doi: 10.1080/16549716.2025.2484111. Epub 2025 Apr 9.
7
Experiences of nurses and patients with the implementation of the CCMDD programme.护士和患者在实施CCMDD项目过程中的经历。
Afr J Prim Health Care Fam Med. 2025 Jan 29;17(1):e1-e9. doi: 10.4102/phcfm.v17i1.4676.
8
Factors Contributing to Retention in Care and Treatment Adherence Among People Living With HIV Returning to Care in South-Eastern Tanzania: A Qualitative Study.坦桑尼亚东南部接受治疗的艾滋病毒感染者护理留存率及治疗依从性的影响因素:一项定性研究
HIV AIDS (Auckl). 2025 Feb 4;17:39-57. doi: 10.2147/HIV.S492673. eCollection 2025.
9
Barriers and facilitators to implementing six monthly multi-month dispensing of antiretroviral therapy in two urban HIV clinics during the COVID-19 Era in Malawi.在马拉维新冠疫情期间,两家城市艾滋病诊所实施抗逆转录病毒疗法六个月多次配药的障碍与促进因素
PLOS Glob Public Health. 2024 Dec 31;4(12):e0003900. doi: 10.1371/journal.pgph.0003900. eCollection 2024.
10
Assessing the impact of COVID-19 on HIV care cascade for people living with HIV in Ethiopia: a retrospective longitudinal study.评估 COVID-19 对埃塞俄比亚 HIV 感染者 HIV 关怀链的影响:一项回顾性纵向研究。
BMJ Open. 2024 Nov 1;14(10):e084244. doi: 10.1136/bmjopen-2024-084244.
患者数量和埃塞俄比亚初级保健的质量:来自常规卫生信息系统和 2014 年服务提供情况评估调查的结果。
BMC Health Serv Res. 2021 May 22;21(1):485. doi: 10.1186/s12913-021-06524-y.
4
Multimonth dispensing of up to 6 months of antiretroviral therapy in Malawi and Zambia (INTERVAL): a cluster-randomised, non-blinded, non-inferiority trial.马拉维和赞比亚长达 6 个月的抗逆转录病毒疗法的多月配给(INTERVAL):一项集群随机、非盲、非劣效性试验。
Lancet Glob Health. 2021 May;9(5):e628-e638. doi: 10.1016/S2214-109X(21)00039-5.
5
Economic evaluation of differentiated service delivery models for HIV treatment in Lesotho: costs to providers and patients.莱索托艾滋病毒治疗差异化服务提供模式的经济评价:提供者和患者的成本。
J Int AIDS Soc. 2021 Apr;24(4):e25692. doi: 10.1002/jia2.25692.
6
Determinants of Six-Month Appointment Spacing Model Utilization Among ART Clients in the Public Health Facilities of Jimma Town, Southwest Ethiopia: Case-Control Study.埃塞俄比亚西南部吉马镇公共卫生设施中接受抗逆转录病毒治疗的患者六个月预约间隔模式利用的决定因素:病例对照研究
HIV AIDS (Auckl). 2021 Feb 4;13:145-156. doi: 10.2147/HIV.S282928. eCollection 2021.
7
Twenty-four-month outcomes from a cluster-randomized controlled trial of extending antiretroviral therapy refills in ART adherence clubs.抗逆转录病毒治疗依从俱乐部延长抗逆转录病毒治疗药物续方的整群随机对照试验的 24 个月结果。
J Int AIDS Soc. 2020 Dec;23(12):e25649. doi: 10.1002/jia2.25649.
8
Factors associated with the utilisation of primary care services: a cross-sectional study in public and private facilities in Albania.与初级保健服务利用相关的因素:在阿尔巴尼亚的公立和私立机构进行的横断面研究。
BMJ Open. 2020 Dec 1;10(12):e040398. doi: 10.1136/bmjopen-2020-040398.
9
Perceived Stigma and Associated Factors Among People Living with HIV Attending ART Clinics in Public Health Facilities of Dessie City, Ethiopia.埃塞俄比亚德西市公共卫生设施中接受抗逆转录病毒治疗的艾滋病毒感染者的感知耻辱感及相关因素
HIV AIDS (Auckl). 2020 Oct 7;12:551-557. doi: 10.2147/HIV.S274019. eCollection 2020.
10
Twelve-Month Outcomes of Community-Based Differentiated Models of Multimonth Dispensing of ART Among Stable HIV-Infected Adults in Lesotho: A Cluster-Randomized Noninferiority Trial.莱索托稳定感染 HIV 的成年人中基于社区的多剂量 ART 差异化模式的 12 个月结局:一项集群随机非劣效性试验。
J Acquir Immune Defic Syndr. 2020 Nov 1;85(3):280-291. doi: 10.1097/QAI.0000000000002439.