Department of Clinical Ophthalmology, University College London (UCL), London, United Kingdom.
Curr Aging Sci. 2023;16(3):168-169. doi: 10.2174/1874609816666230530095410.
Age-related macular degeneration (ARMD or AMD) is a progressive, sight-threatening disease. The pathogenesis of ARMD is complex, involving many factors, such as metabolic, functional, genetic, and environmental factors. Recently, long interspersed nuclear element-1 (L1)- mediated reverse transcription (RT) of RNA into cytoplasmic complementary DNA (cDNA) has been associated with retinal pigment epithelium (RPE) destruction. These findings provide a strong input for a new direction in the management of ARMD, as certain human immunodeficiency virus (HIV) drugs, such as nucleoside reverse transcriptase inhibitors (NRTIs), were found to suppress inflammation and protect cells of the retina.
年龄相关性黄斑变性（ARMD 或 AMD）是一种进行性、威胁视力的疾病。ARMD 的发病机制很复杂，涉及许多因素，如代谢、功能、遗传和环境因素。最近，长散布核元件-1（L1）介导的 RNA 向细胞质互补 DNA（cDNA）的逆转录（RT）与视网膜色素上皮（RPE）破坏有关。这些发现为 ARMD 治疗的新方向提供了有力的依据，因为某些人类免疫缺陷病毒（HIV）药物，如核苷逆转录酶抑制剂（NRTIs），被发现可以抑制炎症并保护视网膜细胞。
