Bakó Eszter, Fehérvári Péter, Garami András, Dembrovszky Fanni, Gunther Emese Eszter, Hegyi Péter, Csupor Dezső, Böszörményi Andrea
Department of Pharmacognosy, Semmelweis University, 26 Üllői Str., H-1089 Budapest, Hungary.
Centre for Translational Medicine, Semmelweis University, 26 Üllői Str., H-1089 Budapest, Hungary.
Pharmaceuticals (Basel). 2023 Jan 19;16(2):144. doi: 10.3390/ph16020144.
Essential oils (EOs) are widely used topically in musculoskeletal disorders (MSDs); however, their clinical efficacy is controversial. Our aim was to find evidence that topical EOs are beneficial as an add-on treatment in MSDs. We performed a systematic review and meta-analysis to summarize the evidence on the available data of randomized controlled trials (RCTs). The protocol of this work was registered on PROSPERO. We used Web of Science, EMBASE, PubMed, Central Cochrane Library and Scopus electronic databases for systematic search. Eight RCTs were included in the quantitative analysis. In conclusion, EO therapy had a favorable effect on pain intensity (primary outcome) compared to placebo. The greatest pain-relieving effect of EO therapy was calculated immediately after the intervention (MD of pain intensity = -0.87; = 0.014). EO therapy had a slightly better analgesic effect than placebo one week after the intervention (MD of pain intensity = -0.58; = 0.077) and at the four-week follow-up as well (MD of pain intensity = -0.52; = 0.049). EO therapy had a beneficial effect on stiffness (a secondary outcome) compared to the no intervention group (MD = -0.77; = 0.061). This systematic review and meta-analysis showed that topical EOs are beneficial as an add-on treatment in reducing pain and stiffness in the investigated MSDs.
精油（EOs）在肌肉骨骼疾病（MSDs）中广泛用于局部治疗；然而，其临床疗效存在争议。我们的目的是寻找证据证明局部使用精油作为MSDs的辅助治疗是有益的。我们进行了一项系统评价和荟萃分析，以总结关于随机对照试验（RCTs）现有数据的证据。这项工作的方案已在国际前瞻性注册系统（PROSPERO）上登记。我们使用科学网、EMBASE、PubMed、考克兰中央对照试验注册库和Scopus电子数据库进行系统检索。八项随机对照试验纳入了定量分析。总之，与安慰剂相比，精油疗法对疼痛强度（主要结局）有良好效果。精油疗法在干预后立即计算出最大的止痛效果（疼痛强度的平均差=-0.87；P=0.014）。在干预后一周（疼痛强度的平均差=-0.58；P=0.077）以及四周随访时（疼痛强度的平均差=-0.52；P=0.049），精油疗法的镇痛效果略优于安慰剂。与未干预组相比，精油疗法对僵硬（次要结局）有有益效果（平均差=-0.77；P=0.061）。这项系统评价和荟萃分析表明，局部使用精油作为辅助治疗在减轻所研究的MSDs的疼痛和僵硬方面是有益的。
