Zagórska Agnieszka, Czopek Anna, Fryc Monika, Jaromin Anna, Boyd Ben J
Department of Medicinal Chemistry, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland.
Pharmaceuticals (Basel). 2023 Jan 19;16(2):151. doi: 10.3390/ph16020151.
Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery and developments in targeting dementia. Several approaches are discussed, such as drug repurposing, the use of small molecules, and phosphodiesterase inhibitors. Furthermore, the review also provides insights into clinical trials of these molecules. Emphasis has been placed on small molecules and multi-target-directed ligands, as well as disease-modifying therapies. Finally, attention is drawn to the possibilities of applications of nanotechnology in managing dementia.
痴呆症通常与神经退行性疾病相关，影响着全球数百万人，主要是老年人。不幸的是，目前仍然没有治疗方法。因此，迫切需要解决这一状况。本综述介绍了针对痴呆症的药物发现和开发的现状。讨论了几种方法，如药物重新利用、小分子的使用和磷酸二酯酶抑制剂。此外，该综述还提供了这些分子的临床试验的见解。重点放在了小分子和多靶点导向配体，以及疾病修饰疗法上。最后，还提到了纳米技术在管理痴呆症方面的应用可能性。
