Kaczyńska Katarzyna, Jampolska Monika, Wojciechowski Piotr, Sulejczak Dorota, Andrzejewski Kryspin, Zając Dominika
Department of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5 St., 02-106 Warsaw, Poland.
Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5 St., 02-106 Warsaw, Poland.
Pharmaceuticals (Basel). 2023 Jan 28;16(2):192. doi: 10.3390/ph16020192.
Lactoferrin (LF) is a multifunctional iron-binding glycoprotein that exhibits a variety of properties, such as immunomodulatory, anti-inflammatory, antimicrobial, and anticancer, that can be used to treat numerous diseases. Lung diseases continue to be the leading cause of death and disability worldwide. Many of the therapies currently used to treat these diseases have limited efficacy or are associated with side effects. Therefore, there is a constant pursuit for new drugs and therapies, and LF is frequently considered a therapeutic agent and/or adjunct to drug-based therapies for the treatment of lung diseases. This article focuses on a review of the existing and most up-to-date literature on the contribution of the beneficial effects of LF on the treatment of lung diseases, including asthma, viral infections, cystic fibrosis, or lung cancer, among others. Although in vitro and in vivo studies indicate significant potency of LF in the treatment of the listed diseases, only in the case of respiratory tract infections do human studies seem to confirm them by demonstrating the effectiveness of LF in reducing episodes of illness and shortening the recovery period. For lung cancer, COVID-19 and sepsis, the reports are conflicting, and for other diseases, there is a paucity of human studies conclusively confirming the beneficial effects of LF.
乳铁蛋白（LF）是一种多功能铁结合糖蛋白，具有多种特性，如免疫调节、抗炎、抗菌和抗癌等，可用于治疗多种疾病。肺部疾病仍然是全球死亡和残疾的主要原因。目前用于治疗这些疾病的许多疗法疗效有限或伴有副作用。因此，人们一直在不断寻求新的药物和疗法，乳铁蛋白经常被视为治疗肺部疾病的治疗剂和/或药物治疗的辅助剂。本文重点回顾了现有最新文献中关于乳铁蛋白对肺部疾病（包括哮喘、病毒感染、囊性纤维化或肺癌等）治疗有益作用的贡献。尽管体外和体内研究表明乳铁蛋白在治疗上述疾病方面具有显著效力，但只有在呼吸道感染的情况下，人体研究似乎通过证明乳铁蛋白在减少发病次数和缩短恢复期方面的有效性来证实了这一点。对于肺癌、新冠病毒病和脓毒症，报告相互矛盾，而对于其他疾病，确凿证实乳铁蛋白有益作用的人体研究很少。
