Department of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Warsaw, Poland.
Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University, Warsaw, Poland.
Blood Press. 2023 Dec;32(1):2212085. doi: 10.1080/08037051.2023.2212085.
Arterial hypertension (HT) is a main, potentially reversible cardiovascular risk factor. Long lasting HT leads to hypertension mediated organ damage (HMOD) of heart, vascular bed, and kidneys. Assessment of HMOD is a standard diagnostic procedure in hypertensive adults and presence of HMOD is associated with increased cardiovascular risk. The assessment of main HMOD markers includes the assessment of left ventricular mass, carotid intima-media thickness, arterial stiffness expressed as pulse wave velocity, and assessment of microcirculation. In contrast to adults, proper interpretation of obtained results of HMOD must be adjusted to age and sex referential values. In the last two decades, numerous studies describing HMOD in children with hypertension have been published, including meta-analyses evaluating various methods of HMOD assessment. Here, we present current state of the art and discuss recommendations on HMOD evaluation in hypertensive children.
动脉高血压（HT）是一个主要的、潜在可逆转的心血管危险因素。长期的 HT 会导致心脏、血管床和肾脏的高血压介导的器官损伤（HMOD）。HMOD 的评估是高血压成年患者的标准诊断程序，HMOD 的存在与心血管风险的增加相关。主要 HMOD 标志物的评估包括左心室质量的评估、颈动脉内膜中层厚度、脉搏波速度表示的动脉僵硬度以及微循环的评估。与成年人不同，必须根据年龄和性别参考值调整对 HMOD 获得结果的适当解释。在过去的二十年中，已经发表了许多描述高血压儿童 HMOD 的研究，包括评估各种 HMOD 评估方法的荟萃分析。在这里，我们介绍了目前的最新技术，并讨论了高血压儿童 HMOD 评估的建议。
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