Clinic for Cardiovascular Diseases, University Clinical Center Nis, Nis, Serbia.
Faculty of Medicine, Nis University, Nis, Serbia.
Curr Vasc Pharmacol. 2024;22(3):180-186. doi: 10.2174/0115701611270174231204110557.
Systemic arterial hypertension (HTN) is the main cause of morbidity and mortality, and HTN crises contribute significantly to an unfavourable clinical course. For decades, HTN crises have been dichotomized into hypertensive emergency (HTN-E) and hypertensive urgency (HTN-U). The main difference between the two is the presence of acute hypertension-mediated organ damage (HMOD) - if HMOD is present, HTN crisis is HTN-E; if not, it is HTN-U. Patients with HTN-E are in a life-threatening situation. They are hospitalized and receive antihypertensive drugs intravenously (IV). On the other hand, patients with HTN-U are usually not hospitalized and receive their antihypertensives orally. We suggest a modification of the current risk stratification scheme for patients with HTN crises. The new category would be the intermediate risk group, more precisely the 'impending HTN-E' group, with a higher risk in comparison to HTN-U and a lower risk than HTN-E. 'Impending HMOD' means that HMOD has not occurred (yet), and the prognosis is, therefore, better than in patients with ongoing HMOD. There are three main reasons to classify patients as having impending HTN-E: excessively elevated BP, high-risk comorbidities, and ongoing bleeding/high bleeding risk. Their combinations are probable. This approach may enable us to prevent some HTNEs by avoiding acute HMOD using a timely blood pressure treatment. This treatment should be prompt but controlled.
系统性动脉高血压(HTN)是发病率和死亡率的主要原因,HTN 危象显著导致临床病程恶化。几十年来,HTN 危象已分为高血压急症(HTN-E)和高血压亚急症(HTN-U)。两者的主要区别在于是否存在急性高血压介导的器官损伤(HMOD)——如果存在 HMOD,则 HTN 危象为 HTN-E;如果不存在,则为 HTN-U。HTN-E 患者处于危及生命的状态。他们需要住院并接受静脉内(IV)降压药物治疗。另一方面,HTN-U 患者通常不住院,接受口服降压药物治疗。我们建议对 HTN 危象患者的当前风险分层方案进行修改。新的类别将是中间风险组,更确切地说是“即将发生的 HTN-E”组,与 HTN-U 相比风险更高,与 HTN-E 相比风险更低。“即将发生的 HMOD”意味着尚未发生 HMOD,因此预后比正在发生 HMOD 的患者更好。将患者归类为即将发生 HTN-E 的主要有三个原因:血压过高、高风险合并症和持续出血/高出血风险。它们的组合是可能的。这种方法可以通过及时的血压治疗来预防一些 HTN-E,从而避免急性 HMOD。这种治疗应该迅速但要控制。