Endocrinology and Metabolism Department, Hippocration Hospital, Athens, Greece.
Nephrology Department, Hippocration Hospital, Athens, Greece.
J Musculoskelet Neuronal Interact. 2023 Jun 1;23(2):285-289.
Patients with altered kidney function are at increased risk of hypocalcemia after denosumab administration. There is however a small number of studies and case reports describing hypocalcemia refractory to treatment. We describe a case of severe hypocalcemia, after the administration of three doses of denosumab, in a young patient with lupus nephritis under corticosteroid coverage and osteopenia. However, more studies are needed in order to extract a safe conclusion about the factors that contribute to the development of severe hypocalcemia in this group of patients.
肾功能改变的患者在接受地舒单抗治疗后发生低钙血症的风险增加。然而，有少数研究和病例报告描述了对地舒单抗治疗无效的低钙血症。我们描述了一例在接受地舒单抗三剂治疗后发生严重低钙血症的年轻狼疮肾炎患者，该患者在接受皮质类固醇治疗的同时伴有骨质疏松症。然而，需要更多的研究来提取关于导致这组患者发生严重低钙血症的因素的安全结论。
Zotero 插件