心脑连接：磁共振图像的表型和遗传见解。
Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images.
机构信息
Department of Statistics and Data Science, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Statistics, Purdue University, West Lafayette, IN 47907, USA.
出版信息
Science. 2023 Jun 2;380(6648):abn6598. doi: 10.1126/science.abn6598.
Abstract
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns with brain gray matter morphometry, white matter microstructure, and functional networks. We identified 80 associated genomic loci ( < 6.09 × 10) for heart MRI traits, which shared genetic influences with cardiovascular and brain diseases. Genetic correlations were observed between heart MRI traits and brain-related traits and disorders. Mendelian randomization suggests that heart conditions may causally contribute to brain disorders. Our results advance a multiorgan perspective on human health by revealing heart-brain connections and shared genetic influences.
摘要
心血管健康与认知和心理健康以复杂的方式相互作用，但人们对心脏-大脑系统的表型和遗传联系知之甚少。我们使用来自 40,000 多名受试者的多器官磁共振成像 (MRI) 数据来量化心脑连接。心脏 MRI 特征与大脑灰质形态、白质微观结构和功能网络显示出多种关联模式。我们确定了 80 个与心脏 MRI 特征相关的基因组位点（<6.09×10），这些特征与心血管疾病和脑部疾病有共同的遗传影响。心脏 MRI 特征与大脑相关特征和疾病之间存在遗传相关性。孟德尔随机化表明，心脏疾病可能会导致大脑疾病。我们的研究结果通过揭示心脑连接和共同的遗传影响，从多器官的角度推进了人类健康的研究。
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