State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China.
Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China.
Biomed Pharmacother. 2023 Aug;164:114928. doi: 10.1016/j.biopha.2023.114928. Epub 2023 May 30.
Chemo-photothermal/photodynamic synergistic therapy is a new effective cancer treatment method to overcome the limitations of single chemotherapy. However, the limited low photothermal conversion efficiency, the hypoxic tumor microenvironment, and premature leakage of the drug constrain their clinical applications. To address these challenges, an all-in-one biodegradable polydopamine-coated UiO-66 framework nanomedicine (DUPM) was developed to co-deliver the drug doxorubicin hydrochloride (DOX) and the excellent photothermal material MoO nanoparticles (NPs). The results showed that DUPM exhibited good physicochemical stability and efficiently accumulated tumor tissues under pH-, glutathione-, and NIR-triggered drug release behaviour. Of note, the synthesized MoO NPs endowed DUPM with self-supporting oxygen production and generated more reactive oxygen species (O and·OH), besides, it induces Mo-mediated redox reaction to deplete excessive glutathione thus relieving tumor hypoxia to enhance PDT, further improving synergistic therapy. Meanwhile, DUPM showed strong absorption in the near-infrared range and high photothermal conversion efficiency at 808 nm (51.50%) to realize photoacoustic imaging-guided diagnosis and treatment of cancer. Compared with monotherapy, the in vivo anti-tumor efficacy results showed that DUMP exerted satisfactory tumor growth inhibition effects (94.43%) with good biocompatibility. This study provides a facile strategy to develop intelligent multifunctional nanoparticles with tumor hypoxia relief for improving synergistic therapy and diagnosis against breast cancer.
化疗-光热/光动力协同治疗是一种克服单一化疗局限性的新的有效癌症治疗方法。然而，有限的低光热转换效率、缺氧的肿瘤微环境和药物的过早泄漏限制了它们的临床应用。为了解决这些挑战，开发了一种一体化可生物降解的聚多巴胺包覆的 UiO-66 框架纳米医学（DUPM），以共同递送盐酸阿霉素（DOX）和优异的光热材料 MoO 纳米粒子（NPs）。结果表明，DUPM 表现出良好的物理化学稳定性，并在 pH、谷胱甘肽和近红外触发的药物释放行为下高效积累肿瘤组织。值得注意的是，合成的 MoO NPs 赋予了 DUPM 自支撑产氧和产生更多的活性氧（O 和·OH）的能力，此外，它还诱导 Mo 介导的氧化还原反应消耗过多的谷胱甘肽，从而缓解肿瘤缺氧以增强 PDT，进一步提高协同治疗效果。同时，DUPM 在近红外范围内表现出很强的吸收能力和在 808nm 处的高光热转换效率（51.50%），以实现光声成像引导的癌症诊断和治疗。与单一疗法相比，体内抗肿瘤疗效结果表明，DUPM 发挥了令人满意的肿瘤生长抑制作用（94.43%），具有良好的生物相容性。本研究为开发具有缓解肿瘤缺氧功能的智能多功能纳米粒子提供了一种简便的策略，以提高协同治疗和诊断乳腺癌的效果。
