Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Gastroenterology, Suining First People's Hospital, Suining, China.
Oncology. 2023;101(8):512-519. doi: 10.1159/000531323. Epub 2023 Jun 1.
Circulating tumor cells (CTCs) may be potential diagnostic biomarkers of various malignancies including gastric cancer. This study aimed to evaluate whether CTCs could be used to facilitate the diagnosis of early gastric cancer (EGC) or precancerous gastric lesions.
The diagnostic study included consecutive patients with EGC, gastric precancerous lesions, or fundic gland polyps admitted to the Gastroenterology Department, Beijing Friendship Hospital Affiliated to Capital Medical University (National Center for Digestive Diseases) between October 2016 and January 2018.
A total of 92 patients were enrolled, including 57 patients with EGC, 14 patients with gastric precancerous lesions, and 21 patients with fundic gland polyps (control group). CTCs were detected in 47.89% (34/71) of patients with EGC/gastric precancerous lesions and 4.76% (1/21) of patients with fundic gland polyps (p < 0.001). CTC detection distinguished EGC/precancerous lesions from fundic gland polyps with an area under the receiver operating characteristic curve of 0.740 (95% confidence interval, 0.640-0.840; p = 0.001), a sensitivity of 49.10%, a specificity of 95.00%, a positive predictive value of 97.00%, and a negative predictive value of 64.90%.
Peripheral blood CTCs are more common in patients with EGC or gastric precancerous lesions than in patients with fundic gland polyps. Measurement of CTCs may be a useful tool to aid in the diagnosis of EGC and precancerous lesions.
循环肿瘤细胞（CTC）可能是包括胃癌在内的各种恶性肿瘤的潜在诊断生物标志物。本研究旨在评估 CTC 是否可用于辅助早期胃癌（EGC）或癌前胃病变的诊断。
该诊断研究纳入了 2016 年 10 月至 2018 年 1 月期间首都医科大学附属北京友谊医院消化内科连续收治的 EGC、胃前病变或胃底腺息肉患者。
共纳入 92 例患者，其中 EGC 患者 57 例，胃前病变患者 14 例，胃底腺息肉患者 21 例（对照组）。在 EGC/胃前病变患者中，有 47.89%（34/71）的患者检测到 CTC，而在胃底腺息肉患者中，仅 4.76%（1/21）的患者检测到 CTC（p < 0.001）。CTCs 的检测区分了 EGC/癌前病变与胃底腺息肉，ROC 曲线下面积为 0.740（95%置信区间，0.640-0.840；p = 0.001），灵敏度为 49.10%，特异性为 95.00%，阳性预测值为 97.00%，阴性预测值为 64.90%。
外周血 CTC 在 EGC 或胃前病变患者中比在胃底腺息肉患者中更为常见。CTC 的测量可能是辅助 EGC 和癌前病变诊断的有用工具。
