Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gene. 2023 Aug 5;876:147519. doi: 10.1016/j.gene.2023.147519. Epub 2023 May 30.
FABP2 is one of the key genes involved in obesity development across different populations. However, there is no comprehensive report about the FABP2 contribution to obesity incidence among Iranians. Hence, the present study was designed to assess the probable role of FABP2 polymorphisms in obesity incidence in the Tehran Cardio- metabolic Genetic Study (TCGS) representative Iran population. Unrelated adults who had BMI information for at least 3 consecutive phases of the TCGS cohort were included. The control and case groups were defined as individuals who always had long-term persistent normal weight (20 < BMI < 25; n = 1526) and individuals who were long-term persistent obese (30 < BMI < 35; n = 1313), respectively. The logistic regression test was used to assess the possible association between SNPs located in and around the FABP2 gene with obesity. Also, we used Haploview and SHEsis to perform haplotype analysis to detect whether or not this chromosomal region is correlated with obesity. We found a gender-dependent association between the rs10857064 FABP2 and the risk of obesity. The presence of the rs10857064-G allele could significantly increase the risk of obesity only in women, not men (OR = 1.26; 95 % CI: 1.02-1.57; p = 0.03). Through haplotype analysis, we also detected that the TG haplotype containing rs7670862 and rs10857064 could significantly enhance the risk of obesity in women, further supporting the central role of rs10857064 in women's long-term obesity risk. In the current study, we revealed that rs10857064-G FABP2 can significantly predispose women to develop obesity. It highlights the importance of different genetic variants in both genders, which could help us to distinguish more efficient obesity screening tests and treatments based on gender in the future.
FABP2 是参与不同人群肥胖发展的关键基因之一。然而，目前还没有关于 FABP2 对伊朗人肥胖发病率的综合报告。因此，本研究旨在评估 FABP2 多态性在 TCGS 代表伊朗人群肥胖发病中的可能作用。将至少具有 TCGS 队列的 3 个连续阶段 BMI 信息的无关成年人纳入研究。对照组和病例组分别定义为始终具有长期持续正常体重（20 < BMI < 25；n = 1526）和长期持续肥胖（30 < BMI < 35；n = 1313）的个体。使用逻辑回归检验评估位于 FABP2 基因内和周围的 SNP 与肥胖之间的可能关联。此外，我们使用 Haploview 和 SHEsis 进行单体型分析，以检测该染色体区域是否与肥胖相关。我们发现 FABP2 基因 rs10857064 与肥胖风险之间存在性别依赖性关联。rs10857064-G 等位基因的存在仅能显著增加女性肥胖的风险，而不能增加男性肥胖的风险（OR = 1.26；95 % CI：1.02-1.57；p = 0.03）。通过单体型分析，我们还发现包含 rs7670862 和 rs10857064 的 TG 单体型可显著增加女性肥胖的风险，进一步支持 rs10857064 在女性长期肥胖风险中的中心作用。在本研究中，我们揭示了 rs10857064-G FABP2 可显著使女性易患肥胖症。这突出了不同遗传变异在两性中的重要性，这有助于我们在未来根据性别区分更有效的肥胖筛查测试和治疗方法。
