超弹性和弹性囊泡在眼部药物传递中的最新趋势和进展。

Recent trends and updates on ultradeformable and elastic vesicles in ocular drug delivery.

机构信息

Pharmaceutical Nanotechnology Research Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.

LV Prasad Eye Institute, Banjara Hill, Hyderabad, Telangana, India.

出版信息

Drug Discov Today. 2023 Aug;28(8):103647. doi: 10.1016/j.drudis.2023.103647. Epub 2023 May 30.

DOI:10.1016/j.drudis.2023.103647

PMID:37263389

Abstract

Ocular drug delivery is enigmatic on account of various physiological precorneal barriers that ultimately hinder efficient drug penetration and corneal absorption. Ultradeformable vesicles embody non-ionic surfactants, edge activators and vesicular builders that provide enormous elasticity and deformability. The elastic vesicles can cross the ocular barriers owing to their peculiar squeezability and distorting ability and, thus, establish an infallible shot for ocular delivery. This review provides an overview of the recent advancements and updates of elastic vesicles as effective ocular drug delivery vehicles.

摘要

由于各种生理前角膜屏障的存在，眼用药物传递具有神秘感，这些屏障最终阻碍了药物的有效渗透和角膜吸收。超变形囊泡包含非离子表面活性剂、边缘活性剂和囊泡构建剂，它们提供了巨大的弹性和变形能力。弹性囊泡由于其独特的可压缩性和变形能力可以穿越眼屏障，因此为眼部给药提供了可靠的途径。本文综述了弹性囊泡作为有效的眼部药物传递载体的最新进展和更新。