Department of Head and Neck Surgery, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Otolaryngol Head Neck Surg. 2023 Nov;169(5):1390-1392. doi: 10.1002/ohn.397. Epub 2023 Jun 2.
Obtaining negative surgical cancer margins is the strongest predictor for the long-term survival of oral cavity squamous cell carcinoma patients. To verify that the tumor has been completely removed, surgeons rely on pathologic evaluation of frozen sections to determine surgical margins, which can be time-consuming and subjective. Herein, we detail the real-time intraoperative use of dynamic optical contrast imaging (DOCI), a novel imaging modality that rapidly distinguishes head and neck cancer from healthy adjacent tissues based on fluorescence decay information from spectral bands in the UV-VIS range. Analysis of DOCI revealed microscopic characterization sufficient for tissue type identification consistent with histology (p < .05). DOCI delivers a clinically relevant tool that may better inform and drive precision surgery, directly impacting surgical outcomes and improving overall survival for our patients.
获得阴性手术切缘是预测口腔鳞状细胞癌患者长期生存的最强预测因子。为了验证肿瘤是否已被完全切除，外科医生依赖于对冷冻切片的病理评估来确定手术切缘，这可能既耗时又主观。在此，我们详细介绍了动态光学对比成像（DOCI）的实时术中应用，这是一种新的成像方式，它基于紫外-可见光谱带中的荧光衰减信息，快速区分头颈部癌症与健康相邻组织。DOCI 的分析显示，其具有足够的微观特征，可与组织学一致进行组织类型识别（p<0.05）。DOCI 提供了一种有临床意义的工具，可能更好地为精准手术提供信息和指导，直接影响手术结果，提高我们患者的总体生存率。
