Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science, Suzhou Medical College of Soochow University, Soochow University, Suzhou, 215000, P. R. China.
State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
Macromol Biosci. 2023 Nov;23(11):e2300191. doi: 10.1002/mabi.202300191. Epub 2023 Jun 15.
Bacterial adhesion and subsequent biofilm formation on the surfaces of synthetic materials imposes a significant burden in various fields, which can lead to infections in patients or reduce the service life of industrial devices. Therefore, there is increasing interest in imbuing surfaces with antibacterial properties. Bioinspired superhydrophobic surfaces with high water contact angles (>150°) exhibit excellent surface repellency against contaminations, thereby preventing initial bacterial adhesion and inhibiting biofilm formation. However, conventional superhydrophobic surfaces typically lack long-term durability and are incapable of achieving persistent efficacy against bacterial adhesion. To overcome these limitations, in recent decades, dual-function superhydrophobic antibacterial surfaces with both bacteria-repelling and bacteria-killing properties have been developed by introducing bactericidal components. These surfaces have demonstrated improved long-term antibacterial performance in addressing the issues associated with surface-attached bacteria. This review summarizes the recent advancements of these dual-function superhydrophobic antibacterial surfaces. First, a brief overview of the fabrication strategies and bacteria-repelling mechanism of superhydrophobic surfaces is provided and then the dual-function superhydrophobic antibacterial surfaces are classified into three types based on the bacteria-killing mechanism: i) mechanotherapy, ii) chemotherapy, and iii) phototherapy. Finally, the limitations and challenges of current research are discussed and future perspectives in this promising area are proposed.
细菌在合成材料表面的黏附和随后的生物膜形成给各个领域带来了重大负担，这可能导致患者感染或降低工业设备的使用寿命。因此，人们越来越有兴趣赋予表面抗菌性能。具有高接触角 (>150°) 的仿生超疏水表面表现出对污染物的优异表面排斥性，从而防止初始细菌黏附并抑制生物膜形成。然而，传统的超疏水表面通常缺乏长期耐久性，并且无法对细菌黏附实现持久的功效。为了克服这些限制，在最近几十年中，通过引入杀菌成分，已经开发出了具有细菌排斥和杀菌功能的双功能超疏水抗菌表面。这些表面在解决与表面附着细菌相关的问题方面表现出了改善的长期抗菌性能。本综述总结了这些双功能超疏水抗菌表面的最新进展。首先，简要概述了超疏水表面的制造策略和细菌排斥机制，然后根据杀菌机制将双功能超疏水抗菌表面分为三类：i) 机械疗法，ii) 化学疗法，和 iii) 光疗。最后，讨论了当前研究的局限性和挑战，并提出了该有前景领域的未来展望。
