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老年炎症性肠病患者的管理:年龄只是一个数字吗?

Managing the older adult with inflammatory bowel disease: is age just a number?

机构信息

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Division of Gastroenterology, Department of Medicine.

出版信息

Curr Opin Gastroenterol. 2023 Jul 1;39(4):268-273. doi: 10.1097/MOG.0000000000000943. Epub 2023 May 23.

DOI:10.1097/MOG.0000000000000943
PMID:37265181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10275506/
Abstract

PURPOSE OF REVIEW

This review summarizes the most recent literature on older adults with inflammatory bowel diseases (IBD). Additionally, we review geriatric syndromes that may be pertinent to the management of older adults with IBD.

RECENT FINDINGS

Traditionally chronological age has been used to risk stratify older adults with IBD, however physiologic status, including comorbidities, frailty, and sarcopenia, are more closely associated with clinical outcomes for older adults. Delaying care for and undertreating older adults with IBD based upon advanced chronologic age alone is associated with worse outcomes, including increased mortality. Treatment decisions should be made considering physiologic status, with an understanding of the differential risks associated with both ongoing disease and treatment. As such, there is an increasing recognition of the impact geriatric syndromes have on older adults with IBD, which need to be further explored.

SUMMARY

Older adults with IBD are less likely to receive advanced therapies and timely surgery. They are also more likely to have adverse outcomes despite having similar disease courses to younger adults with IBD. Focusing on biological age as opposed to chronological age can shift this trajectory and improve quality of care for this growing population of patients with IBD.

摘要

目的综述

本文总结了炎症性肠病(IBD)老年患者的最新文献。此外,我们还回顾了可能与 IBD 老年患者管理相关的老年综合征。

最近的发现

传统上,IBD 老年患者是根据年龄进行风险分层的,但是生理状态,包括合并症、衰弱和肌少症,与老年患者的临床结局更为密切相关。单纯根据年龄来延迟对 IBD 老年患者的治疗和治疗不足,会导致预后较差,包括死亡率增加。治疗决策应考虑生理状态,并了解疾病和治疗相关的差异风险。因此,人们越来越认识到老年综合征对 IBD 老年患者的影响,需要进一步探讨。

总结

IBD 老年患者接受先进治疗和及时手术的可能性较小。尽管他们的疾病进程与年轻的 IBD 患者相似,但他们的不良结局发生率更高。关注生物年龄而不是实际年龄,可以改变这种趋势,提高 IBD 患者这一不断增长的人群的护理质量。